Back to results
US 10,517,990 B2Granted
Thermoreversible hydrogels from the arrested phase separation of elastin-like polypeptides
AssigneeMassachusetts Institute of Technology
InventorsBradley D. Olsen, Matthew J. Glassman, Reginald K. Avery
Life of this patent
Estimating the term…
Abstract
Elastin-like polypeptides (ELPs) form hydrogels upon heating. The polypeptides can comprise the generic sequence (XPAVG)n (SEQ ID NO: 4), wherein independently for each occurrence X can be any one of a number of different natural or unnatural amino acids, and n is chosen to determine the size of the protein. Hydrogels comprising the polypeptides have mechanical properties, including elastic modulus and fracture toughness, required for load-bearing applications.
Claims16
A composition comprising a polypeptide and a solvent;
- wherein the polypeptide has the following sequence (SEQ ID NO:
- 85):
- y1-(XPAVG)n-y2
- wherein, independently for each occurrence,
- X is I or V;
- n is an integer from 5-500;
- and
- y1 is a polypeptide, wherein the polypeptide is selected from the group consisting of MGWGSASGLVG (SEQ ID NO:
- 75), KCTSAGAGAGPEGRGDS (SEQ ID NO:
- 76), MGWGSKCTSAGAGAGPEGRGDSTSGLVG (SEQ ID NO:
- 77), MGWGSKCTSAGAGAGPEGRGDSTSGLVGRGD (SEQ ID NO:
- 78), and MGWGSKCTSAGAGAGPEGRGDSTSGLVGRGDS (SEQ ID NO:
- 79);
- and
- y2 is a polypeptide, wherein the polypeptide is selected from the group consisting of ETTS (SEQ ID NO:
- 80), CRGD (SEQ ID NO:
- 81), RGDSAGAGAGPEGTSCK (SEQ ID NO:
- 82), RGDSETTSRGDSAGAGAGPEGTSCKL (SEQ ID NO:
- 83), and ETTSRGDSAGAGAGPEGTSCKL (SEQ ID NO:
- 84).
17 more elements
Dependencies are inferred from the claim text.