Method for the sterilization of chromatographic material and chromatographic material sterilized according to said method
AssigneeSartorius Stedim Biotech GmbH
InventorsMartin Leuthold, Louis Villain, Florian Taft
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Abstract
The present invention relates to a method for sterilizing a chromatography material, more particularly microporous polymer membranes, to a chromatography material which has been sterilized by the method according to the invention, to the use of the chromatography material sterilized according to the invention for the chromatographic removal of contaminants from a fluid, and to a closed chromatographic filtration system comprising a chromatography material sterilized according to the invention.
Claims16
Method for sterilizing a chromatography material, comprising the steps:
- (a) treating the chromatography material with an aqueous, basically buffered saline solution;
- and
- (c) irradiating the chromatography material treated in step (a) with gamma radiation.
Chromatography material which has been sterilized by a method comprising the steps:
- (a) treating the chromatography material with an aqueous, basically buffered saline solution;
- and
- (c) irradiating the chromatography material treated in step (a) with gamma radiation.
Use of a chromatography material sterilized by a method comprising the steps:
- (a) treating the chromatography material with an aqueous, basically buffered saline solution:
- (c) irradiating the chromatography material treated in step (a) with gamma radiation to give a sterilized chromatography material;
- and
- using the sterilized chromatography material for the chromatographic removal of contaminates from a fluid.
Closed chromatographic filtration system comprising a sterile filtration device comprising a chromatography material sterilized by treating the chromatography material with an aqueous, basically buffered saline solution to give a treated chromatography material;
- and irradiating the treated chromatography material with gamma radiation,
- assembled sterile hoses;
- and
- sterile connections.
Dependencies are inferred from the claim text.