Bioorthogonal turn-on probes
AssigneeThe General Hospital Corporation
InventorsLabros Meimetis, Jonathan Carlson, Ralph Weissleder
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Abstract
This present application relates to fluorescent tetrazine-containing compounds consisting of a single pi-system. For example, a compound of Formula (I): or a salt thereof, wherein: F is a fluorophore, L is a conjugated linker, and Tz is a substituted or unsubstituted tetrazine; wherein the linker bridges the Tz and F moieties in a single conjugated pi-system. Also provided herein are methods of using the compounds provided herein for biomedical imaging.
Claims3
A compound, which is:
- or a salt thereof.
A method for imaging a subject, the method comprising:
- a) administering to the subject an effective amount of a dieneophile conjugated to one or more of a small molecule therapeutic agent, antibody, nanoparticle, polymer, and mixtures thereof;
- b) administering to the subject an effective amount of a compound which is:
- or a salt thereof;
- and
- c) imaging the subject.
A pharmaceutical composition, comprising the compound which is:
- or a salt thereof, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.