Gene delivery system using polymer network
AssigneesInstitute for Basic Science, Postech Academy-Industry Foundation
InventorsWon Jong Kim, Jinhwan Kim
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Abstract
Provided is a gene delivery including a polymer network formed by binding phenylboronic acid, sugar, and a low-molecular weight branched polymer. The gene delivery may be stably maintained in vivo and efficiently deliver a gene specifically to cancer cells, such that the gene delivery system may be usefully used as a gene delivery system for chemotherapy.
Claims6
A gene delivery system comprising a polymer network formed by binding a first polyethyleneimine to phenylboronic acid via amide bonds and a second polyethyleneimine to sugar via amide bonds, and binding the phenylboronic acid bound to the first polyethyleneimine and the sugar bound to the second polyethyleneimine to each other by the phenylboronic acid and a cis-diol of the sugar to form boronate ester binding.
Dependencies are inferred from the claim text.