Back to results
US 10,517,960 B2Granted
Bifunctional polypeptides
AssigneeImmunocore Limited
InventorsBent Karsten Jakobsen, Annelise Brigitte Vuidepot, Yi Li
Life of this patent
Estimating the term…
Abstract
A bifunctional polypeptide comprising a specific binding partner for a peptide-MHC epitope, such as an antibody or T cell receptor, and an immune effector, such as an antibody or a cytokine, the immune effector part being linked to the N-terminus of the peptide-MHC binding part.
Claims6
A bifunctional molecule, comprising:
- a heterodimeric αβ T-Cell Receptor (αβ TCR), wherein the αβ TCR binds specifically to a given pMHC epitope, and
- an immune effector polypeptide,
- wherein:
- the N-terminus of the α chain of the αβ TCR is linked to the C-terminus of a single chain of an immune effector polypeptide comprising CDRs of an anti-CD3 antibody, and
- the bifunctional molecule is capable of binding to the given pMHC epitope and CD3, each on a different cell, and thus simultaneously binding to two different cells.
2 more elements
A bifunctional molecule, comprising:
- a heterodimeric αβ T-Cell Receptor (αβ TCR), wherein the αβ TCR binds specifically to a given pMHC epitope, and
- an immune effector polypeptide,
- wherein:
- the N-terminus of the β chain of the αβ TCR is linked to the C-terminus of a single chain of an immune effector polypeptide comprising CDRs of an anti-CD3 antibody, and
- the bifunctional molecule is capable of binding to the given pMHC epitope and CD3, each on a different cell, and thus simultaneously binding to two different cells.
2 more elements
Dependencies are inferred from the claim text.