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US 10,517,948 B2Granted
Anti-DC-HIL antibodies for cancer diagnosis, prognosis and therapy
AssigneeBoard of Regents, The University of Texas System
InventorsKiyoshi Ariizumi, Ponciano Cruz
Life of this patent
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Abstract
The present disclosure is directed to antibodies that bind to DC-HIL on the surface of myeloid-derived suppressor cells, and thus antagonize the T cell suppressor function of these cells, as well as their use in diagnosing and treating cancers such as melanoma.
Claims8
A method of predicting the progression of melanoma in a subject comprising:
- (a) obtaining a sample from said subject;
- and
- (b) using an antibody-based immunoassay to determine in said sample:
- (i) a DC-HIL level on myeloid-derived suppressor cells (MDSCs) in said subject;
- or
- (ii) the number of DC-HIL-positive MDSCs;
- wherein a higher level of DC-HIL on said MDSCs of step (b)(i) as compared to an MDSC from a non-cancer subject, or a higher number of DC-HIL-positive MDSCs in step (b)(ii), as compared to a non-cancer subject, indicates that said subject will have progression of melanoma, and
- wherein the antibody comprises light chain CDR sequences SEQ ID NOS:
- 1, 2 and 3 and heavy chain CDR sequences SEQ ID NOS:
- 4, 5 and 6.
7 more elements
A method of predicting the response of a subject to melanoma immunotherapy comprising:
- (a) obtaining a sample from said subject;
- and
- (b) using an antibody-based immunoassay to determine in said sample:
- (i) a DC-HIL level on myeloid-derived suppressor cell (MDSCs) in said subject;
- or
- (ii) the number of DC-HIL-positive MDSCs;
- wherein a lower level of DC-HIL on said MDSCs of step (b)(i) as compared to a level in a non-cancer subject, or a lower number of DC-HIL-positive MDSCs in step (b)(ii), as compared to a non-cancer subject, indicates that said subject will have a response to melanoma immunotherapy, and
- wherein the antibody comprises light chain CDR sequences SEQ ID NOS:
- 1, 2 and 3 and heavy chain CDR sequences SEQ ID NOS:
- 4, 5 and 6.
7 more elements
Dependencies are inferred from the claim text.