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US 10,517,944 B2Granted
Therapeutic HPV vaccine combinations
AssigneesJanssen Vaccines & Prevention B.V., Bavarian Nordic A/S
InventorsEvelien M. Bunnik, Jerôme H. H. V. Custers, Gerrit C. Scheper, Selina Khan, Markus Kalla, Katrin Weidner
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Abstract
Vectors, vaccines, vaccine compositions and vaccine combinations for use as therapeutics against HPV18 and/or HPV16 are described.
Claims20
A vaccine combination comprising:
- a) a first vaccine comprising an immunologically effective amount of either
- (i) a recombinant adenovirus vector comprising a first nucleic acid encoding a first polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a second nucleic acid encoding a second polypeptide comprising the amino acid sequence of SEQ ID NO:
- 20, or
- (ii) a first recombinant adenovirus vector comprising a first nucleic acid encoding a first polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a second recombinant adenovirus vector comprising a second nucleic acid encoding a second polypeptide comprising the amino acid sequence of SEQ ID NO:
- 20,
- together with a pharmaceutically acceptable carrier;
- and
- b) a second vaccine comprising an immunologically effective amount of a recombinant Modified Vaccinia Ankara (MVA) vector comprising a third nucleic acid encoding a third polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a fourth nucleic acid encoding a fourth polypeptide comprising SEQ ID NO:
- 20, together with a pharmaceutically acceptable carrier;
- wherein the MVA vector comprises MVA-BN or derivatives thereof.
10 more elements
A recombinant Modified Vaccinia Ankara (MVA) vector comprising:
- (a) a first nucleic acid encoding at least one of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 3, and (b) a second nucleic acid encoding at least one of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 20 and a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 22;
- wherein the MVA vector is MVA-BN or derivatives thereof.
3 more elements
A recombinant MVA vector comprising at least one nucleic acid encoding at least one polypeptide selected from the group consisting of polypeptides comprising the amino acid sequences of SEQ ID NO:
- 1, SEQ ID NO:
- 3, SEQ ID NO:
- 20, and SEQ ID NO:22, wherein the at least one nucleic acid is operably linked to a promoter comprising at least one of the polynucleotide sequences of SEQ ID NO:
- 26 and SEQ ID NO:
- 27.
2 more elements
A method for inducing an immune response against Human Papilloma Virus (HPV) in a subject in need thereof, the method comprising:
- (a) administering to the subject a first vaccine comprising an immunologically effective amount of either
- (i) a recombinant adenovirus vector comprising a first nucleic acid encoding a first polypeptide comprising the amino acid sequence of SEQ ID NO:1 and a second nucleic acid encoding a second polypeptide comprising SEQ ID NO:
- 20, or
- (ii) a first recombinant adenovirus vector comprising a first nucleic acid encoding a first polypeptide comprising the amino acid sequence of SEQ ID NO:1 and a second recombinant adenovirus vector comprising a second nucleic acid encoding a second polypeptide comprising the amino acid sequence of SEQ ID NO:
- 20,
- together with a pharmaceutically acceptable carrier;
- and
- (b) administering to the subject a second vaccine comprising an immunologically effective amount of a recombinant Modified Vaccinia Ankara (MVA) vector comprising a third nucleic acid encoding a third polypeptide comprising the amino acid sequence of SEQ ID NO:1 and a fourth nucleic acid encoding a fourth polypeptide comprising the amino acid sequence of SEQ ID NO:
- 20, together with a pharmaceutically acceptable carrier;
- wherein the first vaccine is administered to the subject as a priming vaccine and the second vaccine is administered to the subject as a boosting vaccine.
7 more elements
Dependencies are inferred from the claim text.