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US 10,517,943 B2Granted
Stable liquid vaccinia virus formulations
AssigneeTransgene S.A.
InventorMélina Chasle
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Abstract
The present invention relates to liquid formulations of poxvirus, in particular vaccinia virus, stable during storage. Such stable liquid formulations comprise a) a poxvirus, preferably a vaccinia virus, b) a pharmaceutically acceptable buffer, c) a monovalent salt, d) a pharmaceutically acceptable disaccharide or sugar alcohol, and e) a pharmaceutically acceptable chelating agent, wherein the pH of the formulation is comprised between 6.5 and 8.5.
Claims21
A liquid formulation comprising:
- a) a poxvirus,
- b) a pharmaceutically acceptable buffer,
- c) a monovalent salt,
- d) a pharmaceutically acceptable disaccharide or sugar alcohol,
- e) a pharmaceutically acceptable chelating agent, and
- f) a C2-C3 alcohol in a concentration of 0.05 to 5% (v/v) and/or sodium glutamate in a concentration lower than 10 mM,
- wherein the pH of the formulation is between 6.5 and 8.5.
4 more elements
Dependencies are inferred from the claim text.