Polypeptide glycopeptide fragments from the V1/V2 and V3 domains of the HIV-1 envelope protein gp 120
AssigneeThe Regents of the University of California
InventorsPhillip Berman, Rachel Doran, Gabriel Byrne, Rebecca Dubois, Javier Morales, Bin Yu, Gerardo Perez, Kathryn Mesa, David Alexander
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Abstract
Creation of HIV-1 vaccine immunogens based on glycopeptide scaffolds containing sequences from the V1/V2/V3 and C3 domains of HIV-1 gp120 that is able to bind multiple broadly neutralizing antibodies when expressed in mammalian cells that incorporate mannose-5 and mannose-9 glycans.
Claims17
A polypeptide comprising of V1/V2 domain of the HIV-1 envelope protein gp120 fused to V3 stem domain of the HIV-1 glycoprotein gp120, wherein the polypeptide does not include the C2 domain of the HIV-1 glycoprotein gp120.
Dependencies are inferred from the claim text.