Immunotherapy for the treatment of cancer
AssigneeUniversity Health Network
InventorsLi Zhang, Jong Bok Lee, Branson Chen
Life of this patent
Estimating the term…
Abstract
Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.
Claims20
A method of treating leukemia or lymphoma in a subject in need thereof, comprising administering to the subject an effective amount of double negative T cells (DNTs) and a cell cycle inhibitor, wherein the DNTs are mature allogenic DNTs that have been expanded in vitro.
Dependencies are inferred from the claim text.