Back to results
US 10,517,919 B2Granted
Selective Nox-1 inhibitor peptides and uses thereof
AssigneesUniversite De Bordeaux, Inserm
InventorsHamid Reza Rezvani, Frédéric Mazurier, Alain Taieb, L'Emira Ghida Harfouche
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel peptides, compositions and methods for the prevention and/or treatment of pathological conditions and diseases associated with NADPH oxidase 1 (Nox1) activity, and/or increased reactive oxygen species (ROS) production. The novel peptides are thus particularly useful for treating and/or preventing cancer, atherosclerosis, angiogenesis, and aging.
Claims14
A peptide consisting of a sequence having at least 90% sequence identity to any of the following sequences:
- PPTVPTR (SEQ ID NO:
- 2)
- PPSVPTR (SEQ ID NO:
- 3)
- PPMVPTR (SEQ ID NO:
- 4)
- PPCVPTR (SEQ ID NO:
- 5)
- PPPVPTR (SEQ ID NO:
- 6)
- PPAVPTR (SEQ ID NO:
- 7)
- PPVVPTR (SEQ ID NO:
- 8)
- PPTVPSR (SEQ ID NO:
- 9)
- PPTVPMR (SEQ ID NO:
- 10)
- PPTVPVR (SEQ ID NO:
- 11)
- PPTVPAR (SEQ ID NO:
- 12)
- QPTAPTR (SEQ ID NO:
- 13)
- PPTLPTR (SEQ ID NO:
- 14)
- PPTIPTR (SEQ ID NO:
- 15)
- PPTAPTR (SEQ ID NO:
- 16)
- PPKVPTR (SEQ ID NO:
- 17)
- QPTVPTR (SEQ ID NO:
- 18)
- APTVPTR (SEQ ID NO:
- 19)
- PPTVPTRPS (SEQ ID NO:
- 20)
- IQSRCCTVT (SEQ ID NO:
- 21)
- PTVPTRP (SEQ ID NO:
- 22)
- TVPTRPS (SEQ ID NO:
- 23)
- RPSPGAI (SEQ ID NO:
- 24)
- SPGAIQS (SEQ ID NO:
- 25)
- PGAIQSR (SEQ ID NO:
- 26)
- GAIQSRC (SEQ ID NO:
- 27)
- AIQSRCC (SEQ ID NO:
- 28)
- IQSRCCT (SEQ ID NO:
- 29)
- QSRCCTV (SEQ ID NO:
- 30)
- SRCCTVT (SEQ ID NO:
- 31)
- QVVAQHSYSA (SEQ ID NO:
- 32)
- QGPEDLGFRQ (SEQ ID NO:
- 33)
- LGFRQGDTVD (SEQ ID NO:
- 34)
- GDTVDVLCEE (SEQ ID NO:
- 35)
- VLCEEPDVPL (SEQ ID NO:
- 36)
- PDVPLAVDQA (SEQ ID NO:
- 37)
- AVDQAWLEGH (SEQ ID NO:
- 38).
71 more elements
Dependencies are inferred from the claim text.