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AssigneeWonkwang University Center for Industry-Academy Cooperation
InventorSung Chul Kim
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Disclosed herein is a pharmaceutical composition for preventing, alleviating or treating neurodegenerative diseases. The pharmaceutical composition contains, as active ingredients, Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum. The pharmaceutical composition is prepared by a method including the steps of: mixing Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum to obtain a mixture, and extracting the mixture to obtain a mixture extract; filtering the mixture extract; concentrating the mixture extract; and drying the mixture extract.
A composition for preventing, alleviating or treating a neurodegenerative disease, the composition containing, as an active ingredient, an extract of a mixture of the herbal materials consisting essentially of Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum, wherein the extract of the mixture is contained in the composition at a concentration of 10 to 200 μg/ml and wherein the composition reduces LPS-induced nitrite production in cultured BV2 microglial cells by at least 30% when provided at a concentration of 50 ug/ml, at least 60% when provided at a concentration of 100 ug/ml, and at least 80% when provided at a concentration of 200 ug/ml.
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