Methods of lowering blood glucose levels in a mammal
AssigneeViaCyte, Inc.
InventorsLaura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
Claims11
A method of lowering blood glucose levels in a human in need thereof, said method comprising the steps of:
- a) transplanting a cell culture comprising, (i) human pancreatic duodenum homeobox 1 (PDX-1) positive pancreatic endoderm cells and (ii) human endocrine precursor cells that express neurogenin 3 (NEUROG3) into the human;
- and
- b) maturing in vivo the transplanted cells of step a) into insulin secreting cells, wherein the insulin secreting cells secrete insulin in response to glucose stimulation, thereby lowering the blood glucose levels of the human.
Dependencies are inferred from the claim text.