Compositions and methods related to hematologic recovery
AssigneeThe Regents of the University of California
InventorJohn P. Chute
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Abstract
In some aspects, the invention relates to populations of hematopoietic cells that are enriched in PTPσ− cells and methods of use thereof.
Claims14
A method for implanting hematopoietic cells into a subject in need thereof, the method comprising:
- obtaining a sample comprising hematopoietic cells;
- contacting the sample with an inhibitor of the PTPσ pathway;
- and
- transplanting the sample into the subject.
A method for promoting hematopoietic reconstitution in a subject in need thereof, the method comprising administering to the subject an inhibitor of a PTPσ pathway, wherein the subject has received an implant comprising hematopoietic cells, or wherein the method further comprises administering hematopoietic cells to the patient before the subject receives the PTPσ pathway inhibitor, simultaneously with the PTPσ pathway inhibitor, or after the subject receives the PTPσ pathway inhibitor.
Dependencies are inferred from the claim text.