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US 10,517,886 B2Granted
Drug formulations
AssigneeAstex Pharmaceuticals, Inc.
InventorsRajashree Joshi-Hangal, Chunlin Tang, Sanjeev Redkar, Harish Ravivarapu
Life of this patent
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Abstract
The invention provides derivatives of decitabine with superior chemical stability and shelf life, with similar physiological activity. The derivatives are provided in a non-aqueous formulation, which further stabilizes the derivatives. Methods of treating one or more myelodysplastic syndromes, leukemia, or solid tumours using the formulations are described.
Claims12
A composition comprising, in a solution:
- a) about 45% to about 85% propylene glycol (w/w);
- b) about 5% to about 45% glycerin (w/w);
- and
- c) about 1% to about 30% ethanol (w/w),
- wherein the solution is substantially anhydrous.
2 more elements
Dependencies are inferred from the claim text.