Compositions comprising decitabine and tetrahydrouridine and uses thereof
AssigneeThe Board of Trustees of the University of Illinois
InventorsJoseph Desimone, Yogen Saunthararajah
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Abstract
Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.
Claims15
A composition for oral administration comprising about 1 mg to about 200 mg decitabine, about 100 mg to about 1000 mg tetrahydrouridine, and a pharmaceutically acceptable excipient wherein decitabine is coated with a degradable coating for sustained release and decitabine is bio-available for about 15 minutes to about 180 minutes after the tetrahydrouridine.
Dependencies are inferred from the claim text.