US 10,517,874 B2 · sGC stimulators

sGC stimulators

AssigneeCyclerion Therapeutics, Inc.

InventorsTakashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie, James Jia

Life of this patent

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Abstract

Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Claims17

Dependent claims

A method of treating sickle cell disease in a subject in need of treatment, comprising administering a therapeutically effective amount of compound I-531

or a pharmaceutically acceptable salt thereof, to the subject in need of treatment.

Dependencies are inferred from the claim text.

Facts

Application

15/406,959Filed 16 Jan 2017 · division

Priority

15 Mar 2013

Published

US 2017/0136019 A118 May 2017

Granted

31 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification27 codes

A61K 31/506
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: not condensed and containing further heterocyclic rings
A61K 31/517
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/519
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with heterocyclic rings
A61K 31/5377
1,4-Oxazines, e.g. morpholine: not condensed and containing further heterocyclic rings, e.g. timolol

Family

Application61/790,637Us provisional application · filed 15 Mar 2013

Application61/914,915Us provisional application · filed 11 Dec 2013

PCT/US2014/028370Parent of this continuation · filed 14 Mar 2014

Application15/215,628Parent of this division · filed 21 Jul 2016

US 2017/0136019 A1Pre-grant publication · published 18 May 2017

US 9,586,937 B2Parent of this division

Application14/775,954Parent of this continuation

US 9,481,689 B2Parent of this continuation

Application15/215,628Parent of this continuation

US 2016/0031903 A1Published application

US 2016/0347738 A1Published application

US 10,517,874 B2This patent

From the US filing history. Foreign family members aren’t listed.