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US 10,517,865 B2Granted
2-pyridone antimicrobial compositions
AssigneeEmergent Product Development Gaithersburg Inc.
InventorsPatrick Roussel, Jutta Heim, Peter Schneider, Christian Bartels, Yaoquan Liu, Glenn Dale, Daniel Milligan
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compounds of Formula I wherein R1, R2, X, and Y are defined herein. These compounds are type II topoisomerase inhibitors and can be used in methods for treating infections caused by gram-positive pathogens, gram-negative pathogens, and drug-resistant strains thereof.
Claims6
A method of treating a bacterial infection in a subject, the method comprising administering to a subject in need thereof an effective amount of a compound having the formula:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- X is, C1-8 alkyl, C1-8 alkoxy, or —N(RX)2, wherein each RX is independently hydrogen, C1-8 alkyl, or C1-8 haloalkyl;
- Y is pyridyl optionally substituted with one group which is —N(RY1)2 or —C1-8 alkyl—N(RY1)2, and optionally substituted by one to two groups that are each independently halogen, C1-8 alkyl, —RY, or C1-8 alkyl—RY;
- RY is nitro, cyano, —ORY1, —SRY1, —N(RY1)2, —C(O)RY1, —C(O)ORY1, —C(O)N(RY1)2, —OC(O)RY1, —OC(O)ORY1, —OC(O)N(RY1)2, —N(RY1)C(O)RY1, —N(RY1)C(O)ORY1, —N(RY1)C(O)N(RY1)2, —S(O)2RY1, —S(O)2ORY1, —S(O)2N(RY1)2, —OS(O)2RY1, —OS(O)2ORY1, —OS(O)2N(RY1)2, —N(RY1)S(O)2RY1, —N(RY1)S(O)2RY1, or —N(RY1)S(O)2N(RY1)2;
- and
- RY1 is independently hydrogen, C1-8 alkyl, or C1-8 haloalkyl.
4 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- X is, C1-8 alkyl, C1-8 alkoxy, or —N(RX)2, wherein each RX is independently hydrogen, C1-8 alkyl, or C1-8 haloalkyl;
- Y is pyridyl optionally substituted with one group which is —N(RY1)2 or —C1-8 alkyl—N(RY1)2, and optionally substituted by one to two groups that are each independently halogen, C1-8 alkyl, —RY, or C1-8 alkyl—RY;
- RY is nitro, cyano, —ORY1, —SRY1, —N(RY1)2, —C(O)RY1, —C(O)ORY1, —C(O)N(RY1)2, —OC(O)RY1, —OC(O)ORY1, —OC(O)N(RY1)2, —N(RY1)C(O)RY1, —N(RY1)C(O)ORY1, —N(RY1)C(O)N(RY1)2, —S(O)2RY1, —S(O)2ORY1, —S(O)2N(RY1)2, —OS(O)2RY1, —OS(O)2ORY1, —OS(O)2N(RY1)2, —N(RY1)S(O)2RY1, —N(RY1)S(O)2RY1, or —N(RY1)S(O)2N(RY1)2;
- and
- RY1 is independently hydrogen, C1-8 alkyl, or C1-8 haloalkyl.
4 more elements
Dependencies are inferred from the claim text.