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US 10,517,862 B2Granted
Fused heterocyclic compound derivative and application thereof
AssigneesNhwa Pharma. Corporation, Wuhan Jiayu Technology Co., Ltd.
InventorsGuisen Zhang, Xudong Cao, Yin Chen, Yifang Zhang, Minquan Yu, Yinli Qiu, Xiangqing Xu, Tan Zhang, Bifeng Liu, Xin Liu
Life of this patent
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Abstract
The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application thereof. The fused heterocyclic compound derivative has the structure of general formula (I), and can be used to treat neuropsychiatric diseases.
Claims11
A compound of Formula (I), or a pharmaceutically acceptable salt or thereof,
- wherein:
- Z is —(CH2)m—, which is unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxy, oxo and C1-5 alkyl, m is an integer of 2˜5;
- Y is O or S;
- Q is N or CH;
- n=1, 2 or 3;
- R1, R2, R3 or R4 is each independently hydrogen, halogen, C1-5 alkyl, wherein the C1-5 alkyl is unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, amino and hydroxy;
- R is phenyl, or a group of Formula (II), Formula (III) or Formula (IV), wherein the above groups are unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, cyano, C1-5 alkyl, C1-5 alkoxyl and hydroxy;
- wherein, X in Formula (II) is O, R5 is H or halogen.
5 more elements
Dependencies are inferred from the claim text.