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US 10,517,859 B2Granted
Gel local anesthetic agent and gel local anesthetic preparation using same
AssigneeTerumo Kabushiki Kaisha
InventorsChisato Iwakiri, Hideka Kikuchi, Koji Nakamura
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Abstract
A gel type local anesthetic agent of the present invention is a local anesthetic agent consisting of a local anesthetic having a tertiary amine and glycyrrhizic acid in which the local anesthetic and glycyrrhizic acid are gelated to form a gel type.
Claims22
A gel type local anesthetic agent comprising
- a complex and water,
- wherein the complex is made by a glycyrrhizic acid and a local anesthetic,
- the local anesthetic has both of a secondary amine and a tertiary amine or both of a primary amine and a tertiary amine and can be prepared as an aqueous solution of the local anesthetic,
- the glycyrrhizic acid is a water soluble salt of glycyrrhizic acid,
- the complex is formed by an interaction between carboxy group of the water soluble salt of glycyrrhizic acid and the amine of the local anesthetics,
- the local anesthetic agent has a gel state formed only by the complex and water,
- the local anesthetic agent does not contain a compound for gelation other than the water soluble salt of glycyrrhizic acid and the local anesthetic, and
- a molar ratio between the water soluble salt of glycyrrhizic acid and the local anesthetic in the local anesthetic agent is in a range of 1:0.5 to 1:10.
5 more elements
A local anesthetic agent consisting of
- water, glycyrrhizic acid and a local anesthetic,
- wherein the local anesthetic has both of a secondary amine and a tertiary amine or both of a primary amine and a tertiary amine and can be prepared as an aqueous solution of the local anesthetic,
- the glycyrrhizic acid is a water soluble salt of glycyrrhizic acid,
- the local anesthetic agent includes a complex formed by a interaction between carboxy group of the water soluble salt of glycyrrhizic acid and the amine of the local anesthetics,
- the local anesthetic agent has a gel state formed by the complex and water.
2 more elements
An anesthetic gel formulation comprising
- a gel matrix comprising a water soluble salt of glycyrrhizic acid and a local anesthetic comprising both of a secondary amine and a tertiary amine or both of a primary amine and a tertiary amine;
- wherein the anesthetic gel formulation does not contain a compound for gelation other than the water soluble salt of glycyrrhizic acid and the local anesthetic.
Dependencies are inferred from the claim text.