Methods of modulating miRNA levels and compositions for use in the same
AssigneeLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
InventorsOmid Khorram, Tsai-Der Chuang
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Abstract
Methods of modulating a miRNA level, such as a miR-29c and/or miR-200c level, in a cell are provided. Aspects of the methods include contacting the cell with an anti-fibrotic miRNA modulating active agent, such as a tranilast active agent. Also provided are compositions for use in practicing the methods. The methods and compositions find use in a variety of applications, including the treatment of fibrotic disorders, such as a uterine leiomyoma.
Claims13
A method of increasing expression of miR-29c, miR-200c and combinations thereof in a cell, the method comprising:
- contacting the cell with an amount of a tranilast active agent effective to increase expression of miR-29c, miR-200c and combinations thereof in the cell.
A method of increasing a cellular miRNA level in a subject, the method comprising:
- administering to the subject an effective amount of a tranilast active agent to increase the cellular miRNA level in the subject, wherein the cellular miRNA is selected from the group consisting of miR-29c, miR-200c and combinations thereof.
Dependencies are inferred from the claim text.