Mast cell inhibition in diseases of the retina and vitreous
AssigneeCornell University
InventorsRandi B. Silver, Nathan O'Connor
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Abstract
This application discloses methods for treating or preventing an ophthalmic retinal vascular permeability, angiogenic or fibroproliferative disease, disorder or condition that involve administering to a patient in need thereof a composition that can inhibit mast cell migration into the vitreous or the retina, mast cell proliferation in the vitreous or the retina, or mast cell secretion into the vitreous or the retina.
Claims6
A method comprising administering cromolyn twice a day to the mammal's eye in an amount effective to decrease vascular endothelial growth factor (VEGF) in the retinal vasculature within the vitreous cavity of the mammal's eye, where the cromolyn is administered with lodoxamide, nicardipine, barnidipine, elgodipine, a dihydropyridine, or a combination thereof to thereby reduce VEGF in the retinal vasculature of the mammal and treat angiogenesis in the retinal vasculature of the mammal's eye.
Dependencies are inferred from the claim text.