Composition and methods of treatment
AssigneeBueberry Therapeutics Limited
InventorsJohn Ridden, Christine Caroline Ridden, David Cook
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Abstract
The present invention relates to a composition comprising nanoparticles formed of a polymer and terbinafine, wherein the nanoparticles comprise particles in the range of 0.5 to 5 nm and/or in the range of 150 to 250 nm. Such compositions are particularly suited, but not limited, to the treatment of fungal nail infections.
Claims16
A composition comprising nanoparticles formed of a polymer and terbinafine, said nanoparticles consisting of two particle size species, wherein
- the first species is in the range of 0.5 to 5 nm;
- and
- the second species is in the range of 150 to 250 nm, and wherein the polymer comprises polyhexamethylene biguanide.
A method of producing a composition for the treatment of a fungal infection comprising mixing a polymer capable of forming nanoparticles with terbinafine under conditions suitable to allow the formation of nanoparticles, wherein:
- a) the nanoparticles are formed under conditions to enable production of nanoparticles in the range of 0.5 to 5 nm and in the range of 150 to 250 nm;
- or
- b) the mixture is further processed so as to only select those nanoparticles in the range of 0.5 to 5 nm and in the range of 150 to 250 nm, and
- wherein the nanoparticles are formed or processed into two distinct particle sizes groups comprising:
- i) a first species in the range of 0.5 to 5 nm;
- and
- ii) a second species in the range of 50 to 250 nm,
- and wherein the polymer comprises polyhexamethylene biguanide.
Dependencies are inferred from the claim text.