Fast dissolving tablet formulations and methods of making thereof
OwnerOwen Murrayinventor
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Abstract
The present disclosure is directed to compositions and methods for the production of a fast dissolving tablets to be used for the delivery of an agent. An agent can be an active pharmaceutical agent or a non-pharmacological agent, which is needed to be delivered by means of a fast dissolving delivery system. The invention solves many industry challenges within the field of fast dissolve technologies, specifically coupling of fast dissolve properties with required physical attributes of strength/robustness required for commercial production and distribution.
Claims7
A fast dissolving tablet formed by the process of
- forming a first solution including the agent and a first carrier in a first solvent, wherein the first carrier is present in the first solution in an amount between, and including, 2% and 20%;
- freeze drying the initial solution into an inner tablet formation;
- forming a second solution including a second carrier in a second solvent, wherein the second solution includes the carrier in an amount between, and including, 2% and 50%;
- applying the second solution to the frozen tablets, wherein the second solution coats the surface of the frozen tablet forming a coated tablet;
- and
- subliming the coated tablet to form the fast dissolving pharmaceutical tablet,
- wherein the fast dissolving tablet has a tensile strength of 1.0 N/mm2 to 2.5 N/mm2.
A fast dissolving tablet containing an effective amount of agent, wherein the tablet comprising:
- a freeze dried inner tablet formation including the agent and a first carrier;
- and
- a sublimed outer coating surrounding the inner tablet formation to form the fast dissolving pharmaceutical tablet, wherein the outer coating includes a second carrier,
- wherein the coated tablet is sublimed to form the fast dissolving tablet,
- wherein the fast dissolving tablet has a tensile strength of 1.0 N/mm2 to 2.5 N/mm2.
Dependencies are inferred from the claim text.