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US 10,517,832 B2Granted
Tamper resistant pharmaceutical formulations
AssigneePurdue Pharma L.P.
InventorsRama Abu Shmeis, Sheetal R. Muley, Xiaohong Shen, Zhixin Zong
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Abstract
Disclosed in certain embodiments is a solid oral dosage form comprising a plurality of particles, each particle comprising (i) a core comprising an active agent susceptible to abuse and an internal adhesion promoter, wherein the cores are (i) dispersed in a matrix comprising a controlled release material or (ii) coated with a controlled release material. The dosage form can also include an alcohol resistant material.
Claims19
A solid oral dosage form comprising a plurality of particles, each particle comprising:
- a core comprising an active agent susceptible to abuse;
- an internal adhesion promoter in an amount of about 0.05% (w/w) to about 10% (w/w) based on total weight of the dosage form;
- and
- an alcohol resistant material in an amount of about 1% (w/w) to about 50% (w/w) based on total weight of the dosage form;
- wherein the cores are (i) dispersed in a matrix comprising a controlled release material or (ii) coated with a controlled release material.
2 more elements
Dependencies are inferred from the claim text.