Back to results
US 10,517,830 B2Granted
Antibody formulations and methods
AssigneeProthena Biosciences Limited
InventorsPatrick Garidel, Isaac Craig Henderson, Pamela Klein
Life of this patent
Estimating the term…
Abstract
Antibody formulations and methods useful for prophylaxis or treatment of amyloidosis, including AA amyloidosis and AL amyloidosis.
Claims9
A lyophilized formulation of an antibody, comprising about:
- (a) 500 mg of a humanized version of antibody 2A4 (ATCC Accession Number PTA-9662) or antibody 7D8 (ATCC Accession Number PTA-9468) or antigen binding fragment thereof;
- (b) 27.2 mg histidine;
- (c) 15.7 mg L-histidine HCl monohydrate;
- (d) 870.2 mg trehalose;
- and
- (e) 2.0 mg polysorbate 20.
3 more elements
A lyophilized formulation of an antibody, comprising:
- (a) a humanized version of antibody 2A4 (ATCC Accession Number PTA-9662) or antibody 7D8 (ATCC Accession Number PTA-9468) or antigen binding fragment thereof;
- (b) L-histidine;
- (c) L-histidine HCl monohydrate;
- (d) trehalose;
- and (e) polysorbate 20 reconstitutable to an aqueous solution wherein:
- (i) the antibody is present at a concentration of about 50 mg/mL;
- (ii) a histidine buffer is present at a concentration of about 25 mM;
- (iii) the trehalose is present at a concentration of about 230 mM;
- (iv) the polysorbate 20 is present at a concentration of about 0.2 g/L;
- and wherein the solution has a pH of about 6.5.
7 more elements
Dependencies are inferred from the claim text.