US 10,517,827 B2 · Dry powder composition comprising long-chain RNA

Abstract

The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

Claims15

Dependent claims

A method for preparing a dry powder comprising a long-chain RNA molecule, wherein the method comprises the steps of:

a) providing a liquid comprising the long-chain RNA molecule,
b) spray-drying the liquid of step a) with a spray-drying device having a drying gas inlet and a drying gas outlet, wherein the drying gas has a temperature at the inlet of at least 85° C., wherein the drying gas has a temperature at the outlet of at least 50° C.,
wherein the dry powder has a residual moisture content of 7% (w/w) or less, wherein the long-chain RNA molecule is in a complex with a cationic or polycationic compound, and wherein the long-chain RNA molecule comprises at least 200 nucleotides.

Dependencies are inferred from the claim text.

Facts

Application

15/575,284Filed 20 May 2016

Priority

EP 1500151720 May 2015

Published

US 2018/0147146 A131 May 2018

Granted

31 Dec 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 9/16
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: agglomerates;…
A61K 9/1682
Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,…:…
A61K 39/145
Viral antigens: orthomyxoviridae, e.g. influenza virus
A61K 48/005
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy:…

Dry powder composition comprising long-chain RNA

Life of this patent

Dry powder composition comprising long-chain RNA

Life of this patent

Abstract

Claims15