Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers
AssigneesThe University of Chicago, The University of North Carolina at Chapel Hill
InventorsWenbin Lin, Chunbai He, Demin Liu
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Abstract
Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described.
Claims13
A nanoscale particle for co-delivery of a plurality of therapeutic agents, wherein the plurality of therapeutic agents comprise at least one non-nucleic acid chemotherapeutic agent and at least one nucleic acid therapeutic agent, said nanoscale particle comprising:
- a core comprising a metal bisphosphonate coordination polymer comprising a multivalent metal ion and a bisphosphonate, wherein the bisphosphonate is a prodrug of a platinum-based chemotherapeutic agent;
- and
- wherein the core is coated with a lipid bilayer comprising (i) a cationic lipid, wherein at least one nucleic acid therapeutic agent is attached to the cationic lipid via electrostatic interactions;
- or (ii) a functionalized lipid, wherein said functionalized lipid is a thiol- or dithiol-functionalized lipid covalently bonded to at least one nucleic acid therapeutic agent.
Dependencies are inferred from the claim text.