Drug delivery devices and methods for drug delivery
AssigneeTARIS Biomedical LLC
InventorHeejin Lee
Life of this patent
Estimating the term…
Abstract
An orifice-free drug delivery device is provided. In an embodiment, the device includes a body having at least one water-permeable wall bounding a reservoir defined within the body. A drug formulation is disposed within the reservoir. The body has an elastic portion and at least one restraining plug closing off an opening of the body. The opening is in fluid communication with the reservoir, and the restraining plug contacts the elastic portion of the body and controls release of the drug from the device by the transient formation of one or more microchannels between the elastic portion of the body and the at least one restraining plug. The elastic portion may define an opening having an inner diameter, which is exceeded by the outer diameter of the restraining plug by at least 3%.
Claims19
A drug delivery device comprising:
- a body having at least one water-permeable wall bounding a reservoir defined within the body, wherein the body comprises an elastic portion;
- a solid drug formulation which comprises a drug, the drug formulation being disposed within the reservoir;
- and
- at least one restraining plug closing off an opening of the body, the opening being in fluid communication with the reservoir, wherein the device is configured to permit, in vivo, water to diffuse through the at least one water-permeable wall and into the reservoir to contact and solubilize the solid drug formulation, and
- wherein the at least one restraining plug contacts the elastic portion of the body and controls release of the solubilized drug from the device by the transient formation of one or more microchannels between, and at the interface of, the elastic portion of the body and the at least one restraining plug.
An intravesical drug delivery device comprising:
- a body having a water-permeable wall bounding a reservoir defined within the body, wherein the water-permeable wall comprises an elastic portion, wherein the Shore durometer of the elastic portion of the body is from about 40 A to about 60 A;
- a drug formulation which comprises a drug, the drug formulation being disposed within the reservoir;
- and
- a restraining plug closing off an opening of the body, the opening being in fluid communication with the reservoir, wherein the Shore durometer of the restraining plug is from about 70 A to about 100 A,
- wherein the restraining plug contacts the elastic portion of the water-permeable wall and controls release of the drug from the device by the transient formation of one or more microchannels between, and at the interface of, the elastic portion of the water-permeable wall and the restraining plug.
An intravesical drug delivery device comprising:
- an annular-shaped body which comprises an elastomeric, water-permeable wall bounding a reservoir defined within the annulus of the annular shaped body, wherein the water-permeable wall comprises an elastic portion;
- a drug formulation which comprises a drug, the drug formulation being disposed within the reservoir;
- and
- a restraining plug disposed and closing off an end of the annulus, wherein the restraining plug contacts the elastic portion of the water-permeable wall,
- wherein the device is configured to release the drug from the device by the transient formation of one or more microchannels between, and at the interface of, the elastic portion of the water-permeable wall and the restraining plug.
Dependencies are inferred from the claim text.