System and method for diagnosis and assessment of cardiovascular disease by comparing arterial supply capacity to end-organ demand

A system for image processing to analyzing a relationship between a blood supply and a blood demand, the system comprising:

• a data storage device storing instructions for determining the blood supply and the blood demand;
• and
• a processor configured to execute the instructions to perform a method including:
• receiving a patient-specific vascular model of vessel geometry of at least a portion of a coronary artery of the patient's heart, wherein the patient-specific vascular model is generated from patient-specific image data of at least a portion of the patient's heart;
• modeling a volume-based supply capacity of the patient's coronary artery based on the patient-specific vascular model, the volume-based supply capacity being the volume of the patient's coronary artery;
• determining a mass or a volume of at least a portion of a myocardium receiving blood from the patient's coronary artery;
• determining an amount of blood demanded by the determined mass or volume of the portion of the myocardium;
• comparing the modeled volume-based supply capacity of the patient's coronary artery to the determined amount of blood demanded by the determined mass or volume;
• generating a patient-specific simulation of blood flow through the patient-specific vascular model of at least the portion of the patient's coronary artery;
• updating the patient-specific simulation of blood flow by modifying a parameter of the patient-specific simulation of blood flow based on the comparison;
• and
• evaluating the patient based on the patient-specific simulation of blood flow.

A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of analyzing a relationship between a blood supply and a blood demand, the method comprising:

• receiving a patient-specific vascular model of vessel geometry of at least a portion of a coronary artery of the patient's heart, wherein the patient-specific vascular model is generated from patient-specific image data of at least a portion of the patient's heart;
• modeling a volume-based supply capacity of the patient's coronary artery based on the patient-specific vascular model, the volume-based supply capacity being the volume of the patient's coronary artery;
• determining a mass or a volume of at least a portion of a myocardium receiving blood from the patient's coronary artery;
• determining an amount of blood demanded by the determined mass or volume of the portion of the myocardium;
• comparing the modeled volume-based supply capacity of the patient's coronary artery to the determined amount of blood demanded by the determined mass or volume;
• generating a patient-specific simulation of blood flow through the patient-specific vascular model of at least the portion of the patient's coronary artery;
• updating the patient-specific simulation of blood flow by modifying a parameter of the patient-specific simulation of blood flow based on the comparison;
• and
• evaluating the patient based on the patient-specific simulation of blood flow.