Low-substituted hydroxypropyl cellulose, production method thereof, and solid preparation
AssigneeShin-Etsu Chemical Co., Ltd.
InventorsYasuyuki Hirama, Aya Tsuchiya
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AssigneeShin-Etsu Chemical Co., Ltd.
InventorsYasuyuki Hirama, Aya Tsuchiya
Estimating the term…
Provided are low-substituted hydroxypropyl cellulose (L-HPC) having a hydroxypropoxy content of from 5 to 16% by weight, and having, on a basis of a dynamic image analysis to divide all particles into fine, spherical, and fibrous particles consisting of long and short fibrous particles, a volume fraction of the long fibrous particles of from 15 to 50% and a volume fraction of the short fibrous particles of from 23 to 60%; and a solid preparation containing the L-HPC. Also provided is a method for producing the L-HPC including the steps: bringing sheet-like or chip-like pulp having a length-weighted average fiber length of from 2.40 to 3.50 mm into contact with an alkali metal hydroxide solution, reacting the resulting alkali cellulose with propylene oxide, and dispersing the resulting reaction product in water containing an acid to partially dissolve it therein, followed by neutralization with an acid to precipitate crude L-HPC.
Low-substituted hydroxypropyl cellulose having a hydroxypropoxy content of from 5 to 16% by weight, and having, on a basis of a dynamic image analysis to divide all particles into fine particles, spherical particles, and fibrous particles consisting of long and short fibrous particles, a volume fraction of the long fibrous particles relative to all of the particles of from 15 to 50% and a volume fraction of the short fibrous particles relative to all of the particles of from 23 to 60%,
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