Fast dissolving pharmaceutical composition
AssigneeFerring B.V.
InventorsVarinder Ahuja, Tejas Gunjikar, Kristin Wannerberger
Life of this patent
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Abstract
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises inulin.
Claims5
A pharmaceutical composition comprising:
- (a) at least one matrix-forming agent that is inulin, wherein the inulin ranges from 30% to 80% of the entire weight of the composition;
- (b) at least one secondary matrix-forming agent that is mannitol,
- wherein the at least one matrix-forming agent and at least one secondary matrix-forming agent form an open matrix network;
- and
- (c) at least one pharmaceutically active ingredient carried by the open matrix network,
- wherein at least 80% of the pharmaceutical composition dissolves within 10 seconds upon contact with an aqueous solution.
A pharmaceutical composition prepared by a process comprising at least a step of sublimating a solvent from a frozen preparation that comprises:
- (a) at least one matrix-forming agent that is inulin, wherein the inulin ranges from 30% to 80% of the entire weight of the composition;
- (b) at least one secondary matrix-forming agent that is mannitol;
- (c) at least one pharmaceutically active ingredient;
- and
- (d) solvent.
A pharmaceutical composition comprising:
- (a) a first matrix-forming agent that is inulin, wherein the inulin ranges from 30% to 80% of the entire weight of the composition;
- (b) a second matrix-forming agent that is mannitol,
- wherein the first matrix-forming agent and the second matrix-forming agent form an open matrix network;
- and
- (c) at least one pharmaceutically active ingredient carried by the open matrix network,
- wherein at least 80% of the pharmaceutical composition dissolves within 10 seconds upon contact with an aqueous solution.
A blister pack having one or more depressions disposed therein, wherein each of the one or more depressions comprises a pharmaceutical composition, wherein the pharmaceutical composition comprises:
- (a) at least one matrix-forming agent that is inulin;
- (b) at least one secondary matrix-forming agent that is mannitol,
- wherein the at least one matrix-forming agent and at least one secondary matrix-forming agent form an open matrix network;
- and
- (c) at least one pharmaceutically active ingredient carried by the open matrix network.
Dependencies are inferred from the claim text.