Method of making a mycoplasma vaccine
OwnerDianna M. Murphy Jordan, Brian Thomas Martinson +3inventors
InventorsDianna M. Murphy Jordan, Brian Thomas Martinson, Christine Margaret Muehlenthaler, Axel Neubauer, Arun V. Iyer
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Abstract
The present invention relates to a method for the preparation of an immunogenic composition for the treatment and/or prophylaxis of mycoplasma infections in a subject comprising the cultivation of mycoplasma bacteria in a serum-reduced or swine serum-free, eukaryotic cell system; obtaining an antigen of the mycoplasma bacteria; and addition of a pharmaceutically acceptable carrier. Further, the present invention relates to the immunogenic composition obtainable by said method and a method for immunizing a subject comprising the administration of said immunogenic composition to a subject.
Claims11
A method for preparing an immunogenic composition for the treatment of mycoplasma infections in a subject comprising:
- co-cultivating a mycoplasma bacteria with MDCK cells in serum-reduced conditions to obtain a bacterin comprising a mycoplasma antigen, wherein the mycoplasma bacteria comprises at least one mycoplasma species selected from Mycoplasma hyorhinis, Mycoplasma hyosynoviae, and Mycoplasma hyopneumoniae;
- and
- adding a pharmaceutically acceptable carrier to the bacterin.
Dependencies are inferred from the claim text.