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US 10,508,095 B2Granted
Method for producing antibiotic from pleosporaceae ulocladium
AssigneeKoninklijke Nederlandse Akademie van Wetenschappen
InventorsJeroen den Hertog, Gisela Johanna van der Velden, Jelmer Hoeksma
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Abstract
Fermentation processes that use fungi of the genus Ulocladium for producing novel compounds that include an 8- or 9-membered cyclic structure, wherein an (E)-1,4-dioxo-but-2-ene moiety is embedded in the cyclic structure. The compounds may be used as medicaments, in particular as medicaments for treating and preventing microbial infections, such as infections by multidrug resistant and/or Gram-positive bacteria.
Claims4
A method for producing a compound comprising an (E)-7-hydroxy-4-oxo-hept-2-enoic acid lactone ring, the method comprising:
- (a) culturing a fungus of the fungal Family of Pleosporaceae of the genus Ulocladium, in a medium conducive to the production of the compound;
- and,
- (b) optionally recovery of the compound.
Dependencies are inferred from the claim text.