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AssigneeCelltrion Inc.
InventorsJoon Sun Yoon, Hwa Jin Lee, Kye Sook Yi, Cheol Min Kim, Byung Pil Lim, Shin Jae Chang, Seung Suh Hong
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The present invention relates to an epitope specific to hepatitis B virus surface antigen and a binding molecule binding to the same for neutralizing hepatitis B virus. Since the epitope provided by the present invention is produced by forming a three-dimensional structure and does not comprise a determinant, by which escape mutation is induced against an administration of existing vaccines or HBIg, a composition comprising an antibody biding to the epitope or a vaccine composition comprising the epitope has a very low possibility of causing a decrease in efficacy due to escape mutation. Therefore, such an antibody or vaccine composition can be very effectively used in prevention and/or treatment of HBV.
A binding molecule for neutralizing hepatitis B virus (HBV), which specifically binds to an epitope that includes the amino acids at positions 110, 118 and 120 of a hepatitis B virus surface antigen (HBsAg), the amino acid sequence of which antigen is set forth in SEQ ID NO:1, wherein the binding molecule is a human monoclonal antibody or a fragment of such an antibody which comprises a polypeptide sequence comprising the CDR regions of SEQ ID NOS:
Dependencies are inferred from the claim text.