Attenuated African swine fever virus vaccine
AssigneeThe Pirbright Institute
InventorsCharles Abrams, Ana-Luisa Reis, Chris Netherton, Linda Dixon, Dave Chapman, Pedro Sanchez-Cordon
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Abstract
The present invention provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes: multigene-family 360 genes 9L, 10L, 11L, 12L, 13L and 14L; and multigene-family 505 genes 1R, 2R, 3R and 4R. The invention further provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the DP148R gene. The present invention also provides a vaccine comprising such an attenuated virus and its use to prevent ASF. Further, the invention relates to intranasal administration of an attenuated ASF virus.
Claims17
An attenuated African Swine Fever (ASF) virus capable of inducing an immune response, which lacks a functional version of the DP148R gene.
A method of attenuating an African Swine Fever (ASF) virus, which comprises the step of partially or completely deleting, or interrupting the expression of, the following genes:
- multigene-family 360 genes 9L, 10L, 11 L, 12L, 13L and 14L;
- and
- multigene-family 505 genes 1R, 2R, 3R and 4R;
- or
- which comprises the step of partially or completely deleting, or interrupting the expression of, the DP148R gene.
Dependencies are inferred from the claim text.