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US 10,507,233 B2Granted
Universal N-glycan binding reagent
AssigneeNew England Biolabs, Inc.
InventorsMinyong Chen, Xiaofeng Shi, James C. Samuelson, Christopher H. Taron
Life of this patent
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Abstract
Methods of capturing N-glycan linked glycomolecules including N-glycans, N-glycopeptides and N-glycoproteins are described. The methods provide substantially unbiased capture of charged and uncharged N-glycans and/or N-glycan linked glycomoleules. Binding reagents for substantially unbiased binding of N-glycans and/or N-glycan linked glycomolecules are also described.
Claims8
A protein comprising a non-naturally occurring amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 2 and mutations at least at two positions selected from positions that correspond to positions 42, 43, 44, 61, and 62 in SEQ ID NO:2.
Dependencies are inferred from the claim text.