# US 10,504,250 B2 · Systems and methods for correcting mismatch induced by respiratory motion in positron emission tomography image reconstruction

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- Number: US 10,504,250 B2
- Document ID: US10504250B2
- Status: Granted
- Kind: B2
- Application number: 15/881,765
- Filed: 2018-01-27
- Published: 2019-08-01
- Granted: 2019-12-10
- Earliest claimed: 2018-01-27
- Assignees: Uih America, Inc.
- Applicants: Uih America, Inc.
- Inventors: Jizhe Wang; Tao Feng; Hongdi Li
- Web page: https://patentgrep.com/patent/US10504250B2

## CPC

- G06T 12/10: Image preprocessing, e.g. calibration, positioning of sources or scatter correction
- A61B 6/037: {Emission tomography}
- A61B 6/5235: {combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT}
- A61B 6/5264: {due to motion}
- A61B 6/5288: {involving retrospective matching to a physiological signal}
- G06T 7/11: Region-based segmentation
- G06T 7/174: involving the use of two or more images
- G06T 7/20: Analysis of motion (motion estimation for coding, decoding, compressing or decompressing digital video signals H04N19/43, H04N19/51)
- G06T 7/32: using correlation-based methods
- G06T 11/005
- G06T 2207/10081: Computed x-ray tomography [CT]
- G06T 2207/10088: Magnetic resonance imaging [MRI]
- G06T 2207/10104: Positron emission tomography [PET]
- G06T 2207/30061: Lung
- G06T 2211/408: Dual energy
- G06T 2211/412: Dynamic
- G06T 2211/421: Filtered back projection [FBP]
- G06T 2211/424: Iterative
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The disclosure relates to PET imaging systems and methods. The systems may execute the methods to obtain an anatomical image and PET data of a subject, and gate the PET data into a plurality of bins. The systems may execute the methods to reconstruct a plurality of gated PET images based on the gated PET data. The systems may execute the methods to determine a motion vector field corresponding to a target respiratory phase with respect to a reference respiratory phase relating to the anatomical image. The systems may execute the methods to obtain a respiratory phase-matched anatomical image for the target respiratory phase by transforming a VOI in the anatomical image based on the motion vector field corresponding to the target respiratory phase with respect to the reference respiratory phase, and reconstructing an attenuation corrected PET image corresponding to the target respiratory phase.

## Claims

### Claim 1

A method for image processing implemented on at least one machine, each of which includes a processor and a storage device, the method comprising:
obtaining an anatomical image of a subject;
obtaining positron emission tomography (PET) data of the subject;
gating the PET data into a plurality of bins, the plurality of bins corresponding to a plurality of respiratory phases;
reconstructing, based on the gated PET data, a plurality of gated PET images, each gated PET image of the plurality of gated PET images corresponding to a respiratory phase of the plurality of respiratory phases;
determining, based on the plurality of gated PET images and the anatomical image, a motion vector field corresponding to a target respiratory phase with respect to a reference respiratory phase relating to the anatomical image;
obtaining a respiratory phase-matched anatomical image for the target respiratory phase by transforming a volume of interest (VOI) in the anatomical image based on the motion vector field corresponding to the target respiratory phase with respect to the reference respiratory phase; and
reconstructing an attenuation corrected PET image corresponding to the target respiratory phase based on the respiratory phase-matched anatomical image and the gated PET data.

### Claim 2 (depends on 1)

The method of claim 1, wherein
the PET data includes a first portion and a second portion,
the first portion is affected more by a respiratory motion of the subject than the second portion, and
the first portion corresponds to the VOI in the anatomical image.

### Claim 3 (depends on 1)

The method of claim 1, wherein the determining a motion vector field corresponding to a target respiratory phase with respect to a reference respiratory phase comprises:
identifying, based on the plurality of gated PET images, the reference respiratory phase that matches a respiratory phase of the anatomical image among the plurality of respiratory phases; and
determining the motion vector field corresponding to the target respiratory phase based on a gated PET image corresponding to the target respiratory phase and a reference gated PET image corresponding to the reference respiratory phase.

### Claim 4 (depends on 3)

The method of claim 3, wherein the identifying the reference respiratory phase that matches the respiratory phase of the anatomical image comprises:
identifying one or more sub-regions in the anatomical image, the one or more sub-regions corresponding to at least a portion of a lung and a portion of a liver of the subject; and
determining, based on the identified one or more sub-regions in the anatomical image and one or more corresponding portions in each gated PET image of the plurality of gated PET images, the reference respiratory phase that matches the respiratory phase of the anatomical image among the plurality of the respiratory phases.

### Claim 5 (depends on 4)

The method of claim 4, wherein the one or more sub-regions include a first sub-region and a second sub-region, and the identifying one or more sub-regions in the anatomical image comprises:
segmenting a left lung and a right lung of the subject in the anatomical image;
determining the first sub-region based on the left lung; and
determining the second sub-region based on the right lung.

### Claim 6 (depends on 4)

The method of claim 4, wherein the determining the reference respiratory phase that matches the respiratory phase of the anatomical image among the respiratory phases comprises:
determining, for each of the identified one or more sub-regions of the anatomical image, a candidate reference respiratory phase based on the sub-region of the anatomical image and corresponding portions in the plurality of gated PET images; and
designating one candidate reference respiratory phase from the candidate reference respiratory phases as the reference respiratory phase that matches the respiratory phase of the anatomical image.

### Claim 7 (depends on 6)

The method of claim 6, wherein, for a sub-region in the anatomical image, the determining a candidate reference respiratory phase of the anatomical image comprises:
determining, for each of the plurality of gated PET images, a similarity between the sub-region in the anatomical image and the corresponding portion in the gated PET image;
identifying a highest similarity among the determined similarities; and
designating the respiratory phase of the gated PET image with the highest similarity as the candidate reference respiratory phase of the anatomical image.

### Claim 8 (depends on 1)

The method of claim 1, further comprising segmenting the VOI in the anatomical image, and wherein the segmenting the VOI in the anatomical image comprises:
segmenting, in the anatomical image, one or more bones surrounding the thoracic and abdominal cavity of the subject located within the scanning region;
determining one or more edge points of the one or more bones; and
determining the VOI based on the one or more edge points.

### Claim 9 (depends on 1)

The method of claim 1, further comprising:
determining, for each respiratory phase, a motion vector field corresponding to the respiratory phase by an image registration;
for each respiratory phase, obtaining a respiratory phase-matched anatomical image by transforming the VOI in the anatomical image to generate a corrected anatomical image corresponding to the respiratory phase based on the corresponding motion vector field; and
reconstructing, for each respiratory phase, an attenuation corrected PET image corresponding to the respiratory phase based on the corresponding corrected anatomical image and the gated PET data.

### Claim 10 (depends on 1)

The method of claim 1, wherein the anatomical image is at least one of a computed tomography (CT) image or a magnetic resonance (MR) image.

### Claim 11

A system, comprising:
at least one processor; and
at least one storage medium for storing instructions, the instructions, when executed by the at least one processor, causing the system to perform a method including:
obtaining an anatomical image of a subject;
obtaining positron emission tomography (PET) data of the subject;
gating the PET data into a plurality of bins, the plurality of bins corresponding to a plurality of respiratory phases;
reconstructing, based on the gated PET data, a plurality of gated PET images, each gated PET image of the plurality of gated PET images corresponding to a respiratory phase of the plurality of respiratory phases;
determining, based on the plurality of gated PET images and the anatomical image, a motion vector field corresponding to a target respiratory phase with respect to a reference respiratory phase relating to the anatomical image;
obtaining a respiratory phase-matched anatomical image for the target respiratory phase by transforming a volume of interest (VOI) in the anatomical image based on the motion vector field corresponding to the target respiratory phase with respect to the reference respiratory phase; and
reconstructing an attenuation corrected PET image corresponding to the target respiratory phase based on the respiratory phase-matched anatomical image and the gated PET data.

### Claim 12 (depends on 11)

The system of claim 11, wherein:
the PET data includes a first portion and a second portion,
the first portion is affected more by a respiratory motion of the subject than the second portion, and
the first portion corresponds to the VOI in the anatomical image.

### Claim 13 (depends on 11)

The system of claim 11, wherein the determining a motion vector field corresponding to a target respiratory phase with respect to a reference respiratory phase comprises:
identifying, based on the plurality of gated PET images, the reference respiratory phase that matches a respiratory phase of the anatomical image among the plurality of respiratory phases; and
determining the motion vector field corresponding to the target respiratory phase based on a gated PET image corresponding to the target respiratory phase and a reference gated PET image corresponding to the reference respiratory phase.

### Claim 14 (depends on 13)

The system of claim 13, wherein the identifying the reference respiratory phase that matches the respiratory phase of the anatomical image comprises:
identifying one or more sub-regions in the anatomical image, the one or more sub-regions corresponding to at least a portion of a lung and a portion of a liver of the subject; and
determining, based on the identified one or more sub-regions in the anatomical image and one or more corresponding portions in each gated PET image of the plurality of gated PET images, the reference respiratory phase that matches the respiratory phase of the anatomical image among the plurality of the respiratory phases.

### Claim 15 (depends on 14)

The system of claim 14, wherein the one or more sub-regions include a third sub-region and a fourth sub-region, and the identifying one or more sub-regions in the anatomical image comprises:
segmenting a left lung and a right lung of the subject in the anatomical image;
determining the third sub-region based on the left lung; and
determining the fourth sub-region based on the right lung.

### Claim 16 (depends on 14)

The system of claim 14, wherein the determining the reference respiratory phase that matches the respiratory phase of the anatomical image among the respiratory phases comprises:
determining, for each of the identified one or more sub-regions of the anatomical image, a candidate reference respiratory phase based on the sub-region of the anatomical image and corresponding portions in the plurality of gated PET images; and
designating one candidate reference respiratory phase from the candidate reference respiratory phases as the reference respiratory phase that matches the respiratory phase of the anatomical image.

### Claim 17 (depends on 16)

The system of claim 16, wherein, for a sub-region in the anatomical image, the determining a candidate reference respiratory phase of the anatomical image comprises:
determining, for each of the plurality of gated PET images, a similarity between the sub-region in the anatomical image and the corresponding portion in the gated PET image;
identifying a highest similarity among the determined similarities; and
designating the respiratory phase of the gated PET image with the highest similarity as the candidate reference respiratory phase of the anatomical image.

### Claim 18 (depends on 11)

The system of claim 11, further comprising segmenting the VOI in the anatomical image, and wherein the segmenting the VOI in the anatomical image comprises:
segmenting, in the anatomical image, one or more bones surrounding the thoracic and abdominal cavity of the subject located within the scanning region;
determining one or more edge points of the one or more bones; and
determining the VOI based on the one or more edge points.

### Claim 19 (depends on 11)

The system of claim 11, further comprising:
determining, for each respiratory phase, a motion vector field corresponding to the respiratory phase by an image registration;
for each respiratory phase, obtaining a respiratory phase-matched anatomical image by transforming the VOI in the anatomical image to generate a corrected anatomical image corresponding to the respiratory phase based on the corresponding motion vector field; and
reconstructing, for each respiratory phase, an attenuation corrected PET image corresponding to the respiratory phase based on the corresponding corrected anatomical image and the gated PET data.

### Claim 20

A non-transitory computer-readable storage medium storing instructions that, when executed by at least one processor of a system, cause the system to perform a method, the method comprising:
obtaining an anatomical image of a subject;
obtaining positron emission tomography (PET) data of the subject;
gating the PET data into a plurality of bins, the plurality of bins corresponding to a plurality of respiratory phases;
reconstructing, based on the gated PET data, a plurality of gated PET images, each gated PET image of the plurality of gated PET images corresponding to a respiratory phase of the plurality of respiratory phases;
determining, based on the plurality of gated PET images and the anatomical image, a motion vector field corresponding to a target respiratory phase with respect to a reference respiratory phase relating to the anatomical image;
obtaining a respiratory phase-matched anatomical image for the target respiratory phase by transforming a volume of interest (VOI) in the anatomical image based on the motion vector field corresponding to the target respiratory phase with respect to the reference respiratory phase; and
reconstructing an attenuation corrected PET image corresponding to the target respiratory phase based on the respiratory phase-matched anatomical image and the gated PET data.