# US 10,502,803 B2 · Magnetic resonance imaging based on altering the shape of the inversion region in pulsed arterial spin labeling > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,502,803 B2 - Document ID: US10502803B2 - Status: Granted - Kind: B2 - Application number: 15/156,281 - Filed: 2016-05-16 - Published: 2016-11-17 - Granted: 2019-12-10 - Earliest claimed: 2015-05-15 - Assignees: The Regents of the University of California - Applicants: The Regents of the University of California - Inventors: Jia Guo; Eric C. Wong - Web page: https://patentgrep.com/patent/US10502803B2 ## CPC - G01R 33/56366: {Perfusion imaging} - G01R 33/5602: {by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse} - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) ## Abstract Techniques, systems and apparatus are described for magnetic resonance imaging by modifying the shape/thickness of an excitation/inversion slab. For instance, the inversion slab can be shaped as a wedge to improve temporal signal-to-noise ratio (tSNR) of arterial spin labeling (ASL) experiments by matching the temporal bolus width with the inter-pulse spacing in different feeding arteries. The shape/thickness of the excitation/inversion slab across the X-Y plane can be modified by modulating the movement of the “on-resonance” plane in space by the combination of conventional slice-selective (SS) adiabatic fast passage (AFP) and additional in-plane gradient pulses. Using this method, a computer can generate different shapes of the excitation/inversion slab. ## Claims ### Claim 1 A method of magnetic resonance imaging (MRI) by operating an MRI system, comprising: generating RF pulses that, when applied to a tissue of interest via the MRI system, create a slab within the tissue of interest in which magnetic inversion is generated; modifying a shape of the slab having the magnetic inversion by modulating a plurality of in-plane gradients on a thickness of the slab, wherein the modifying the shape of the slab comprises applying a hyperbolic secant inversion pulse with sech/tanh modulation in amplitude and frequency and a Z gradient; measuring one or more of velocities and lengths of at least some of a plurality of feeding arteries in the inversion slab; and assigning an inversion thickness of the inversion slab to at least some of the plurality of feeding arteries by matching a temporal bolus width with an inter-pulse spacing of the at least some of the plurality of feeding arteries. ### Claim 2 (depends on 1) The method of claim 1, wherein the generating of the slab having magnetic inversion comprises: applying a constant gradient pulse; applying an adiabatic fast passage radiofrequency pulse for slice-selection, wherein a frequency of the adiabatic fast passage radiofrequency pulse moves from one side to the other within its frequency sweeping range; and applying an on-resonance frequency to generate a plane in space where magnetization is rapidly perturbed. ### Claim 3 (depends on 1) The method of claim 1, wherein the Z gradient is a constant Z gradient. ### Claim 4 (depends on 1) The method of claim 1, wherein the Z gradient is a non-constant Z gradient. ### Claim 5 (depends on 1) The method of claim 1, wherein modifying the shape of the inversion slab results in a wedge-shaped inversion. ### Claim 6 (depends on 1) The method of claim 1, further comprising: adding a linear modulation along a predetermined direction to a frequency modulation function and a Z gradient waveform to maintain adiabatic properties of the adiabatic fast passage radiofrequency pulse for slice-selection. ### Claim 7 (depends on 6) The method of claim 6, wherein the Z gradient waveform is a constant Z gradient waveform. ### Claim 8 (depends on 6) The method of claim 6, wherein the Z gradient waveform is a non-constant Z gradient waveform. ### Claim 9 (depends on 1) The method of claim 1, wherein the shape of the inversion slab is modified when one or more velocities in one or more blood vessels change. ### Claim 10 A non-transitory computer-readable storage medium embodying instructions to cause a magnetic resonance imaging system to perform operations comprising: generating an inversion slab; modifying a shape of the inversion slab by modulating a plurality of in-plane gradients on a thickness of the inversion slab, wherein the modifying the shape of the slab comprises applying a hyperbolic secant inversion pulse with sech/tanh modulation in amplitude and frequency and a Z gradient; measuring one or more of velocities and lengths of at least some of a plurality of feeding arteries in the inversion slab; and assigning an inversion thickness of the inversion slab to at least some of the plurality of feeding arteries by matching a temporal bolus width with an inter-pulse spacing of the at least some of the plurality of feeding arteries. ### Claim 11 (depends on 10) The non-transitory computer-readable storage medium of claim 10 wherein the generating of the inversion slab comprises: applying a constant gradient pulse; applying an adiabatic fast passage radiofrequency pulse for slice-selection, wherein a frequency of the adiabatic fast passage radiofrequency pulse moves from one side to the other within its frequency sweeping range; and applying an on-resonance frequency to generate a plane in space where magnetization is rapidly perturbed. ### Claim 12 (depends on 10) The non-transitory computer-readable storage medium of claim 10, wherein the Z gradient is a constant Z gradient. ### Claim 13 (depends on 10) The non-transitory computer-readable storage medium of claim 10, wherein the Z gradient is a non-constant Z gradient. ### Claim 14 (depends on 10) The non-transitory computer-readable storage medium of claim 10, wherein modifying the shape of the inversion slab results in a wedge-shaped inversion. ### Claim 15 (depends on 10) The non-transitory computer-readable storage medium of claim 10 further comprises: adding a linear modulation along a predetermined direction to a frequency modulation function and a Z gradient waveform to maintain adiabatic properties of the adiabatic fast passage radiofrequency pulse for slice-selection. ### Claim 16 (depends on 15) The non-transitory computer-readable storage medium of claim 15, wherein the Z gradient waveform is a constant Z gradient waveform. ### Claim 17 (depends on 15) The non-transitory computer-readable storage medium of claim 15, wherein the Z gradient waveform is a non-constant Z gradient waveform. ### Claim 18 (depends on 10) The non-transitory computer-readable storage medium of claim 10, wherein the shape of the inversion slab is modified when one or more velocities in one or more blood vessels change. ### Claim 19 A magnetic resonance imaging (MRI) system, comprising: a scanner comprising a magnet, gradient coils and a radio frequency (RF) system to perform operations comprising: applying a gradient field and generating RF pulses to a tissue of interest to create a slab within the tissue of interest in which magnetic inversion is generated, modifying a shape of the slab having the magnetic inversion by modulating a plurality of in-plane gradients on a thickness of the slab, and acquiring magnetic resonance signals based on the applied RF pulses, wherein modifying the shape of the inversion slab comprises applying a hyperbolic secant inversion pulse with sech/tanh modulation in amplitude and frequency and a Z gradient; and a data processing system in communication with the scanner to receive the acquired magnetic resonance signals and process the received magnetic resonance signal to generate MRI images of the tissue of interest to improve the temporal signal-to-noise ratio (tSNR), the data processing system configured to: measure one or more of velocities and lengths of at least some of a plurality of feeding arteries in the inversion slab; and assign an inversion thickness of the inversion slab to at least some of the plurality of feeding arteries by matching a temporal bolus width with an inter-pulse spacing of the at least some of the plurality of feeding arteries. ### Claim 20 (depends on 19) The system of claim 19, wherein the generating of the slab having magnetic inversion comprises: applying a constant gradient pulse; applying an adiabatic fast passage radiofrequency pulse for slice-selection, wherein a frequency of the adiabatic fast passage radiofrequency pulse moves from one side to the other within its frequency sweeping range; and applying an on-resonance frequency to generate a plane in space where magnetization is rapidly perturbed. ### Claim 21 (depends on 19) The system of claim 19, wherein the Z gradient is a constant Z gradient. ### Claim 22 (depends on 19) The system of claim 19, wherein the Z gradient is a non-constant Z gradient. ### Claim 23 (depends on 19) The system of claim 19, wherein modifying the shape of the slab results in a wedge-shaped inversion. ### Claim 24 (depends on 19) The system of claim 19, wherein the scanner is configured to: add a linear modulation along a predetermined direction to a frequency modulation function and a Z gradient waveform to maintain adiabatic properties of the adiabatic fast passage radiofrequency pulse for slice-selection. ### Claim 25 (depends on 21) The system of claim 21, wherein the Z gradient waveform is a constant Z gradient waveform. ### Claim 26 (depends on 21) The system of claim 21, wherein the Z gradient waveform is a non-constant Z gradient waveform. ### Claim 27 (depends on 19) The system of claim 19, wherein the shape of the slab is modified when one or more velocities in one or more blood vessels change.