# US 10,502,747 B2 · Systems and methods using biomarker panel data > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,502,747 B2 - Document ID: US10502747B2 - Status: Granted - Kind: B2 - Application number: 13/756,129 - Filed: 2013-01-31 - Published: 2013-09-12 - Granted: 2019-12-10 - Earliest claimed: 2012-01-31 - Assignees: Cardiac Pacemakers, Inc.; MUSC Foundation for Research Development - Applicants: Cardiac Pacemakers, Inc.; MUSC Foundation for Research Development - Inventors: Craig M. Stolen; Timothy E. Meyer; Milan Seth; Francis G. Spinale; Nicholas David Wold - Web page: https://patentgrep.com/patent/US10502747B2 ## CPC - G01N 33/6893: {related to diseases not provided for elsewhere} - A61B 5/0031: {Implanted circuitry} - A61B 5/076: {Permanent implantation} - A61B 5/14503: {invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence)} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)} - A61N 1/3627: {for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy} - A61N 1/36557: {controlled by chemical substances in blood} - A61N 1/3956: {Implantable devices for applying electric shocks to the heart, e.g. for cardioversion} - G01N 2800/52: Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data with respect to medical devices and methods, amongst other things. In an embodiment, the disclosure can include a method of predicting the likelihood of response to CRT therapy. The method can include quantifying levels of one or more biomarkers in a biological sample of a patient, analyzing the quantified levels to determine response to CRT therapy, wherein a panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. Other embodiments are also included herein. ## Claims ### Claim 1 A method of treating a patient with CRT therapy comprising: selecting a patient exhibiting heart failure symptoms and lacking a CRT device; quantifying levels of a panel of biomarkers in a biological sample of the patient; analyzing the quantified levels to determine response to CRT therapy with an external medical device comprising a microprocessor, wherein the microprocessor analyzes the quantified levels comprising comparing quantified levels to threshold levels to determine likelihood of response to CRT therapy; and places the patient into one of a set of categories using the quantified levels, the set of categories including at least one of CRT therapy responders, CRT therapy non-responders, and indeterminate response; referring the patient for CRT device implant if the patient is in the CRT therapy responders category; the panel of biomarkers comprising at least CRP, sST2, TIMP-1, and TIMP-2. ### Claim 2 (depends on 1) The method of claim 1, further comprising implanting a CRT device if the patient is in the CRT therapy responders category. ### Claim 3 (depends on 1) The method of claim 1, the panel of biomarkers further including at least one additional biomarker selected from the group consisting of SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, MMP-2, MMP-9, and TIMP-4. ### Claim 4 (depends on 1) The method of claim 1, further comprising selecting a patient that is not indicated for CRT therapy. ### Claim 5 (depends on 1) The method of claim 1, the heart failure symptoms comprising one or more of cardiac pump function, fluid accumulation, activity/exercise tolerance, kidney and cerebral/cognitive function. ### Claim 6 A method of treating a patient that is receiving CRT therapy: selecting a patient that is receiving CRT therapy; quantifying levels of a panel of biomarkers in a biological sample of the patient; analyzing the quantified levels to determine an expected response to CRT therapy with an external medical device comprising a microprocessor, wherein the microprocessor compares the expected response to CRT therapy to the patient's actual response to CRT therapy; and adjusts parameters of the CRT therapy if the patient's actual response to CRT therapy is worse than the expected response to CRT therapy; the panel of biomarkers comprising at least CRP, sST2, TIMP-1, and TIMP-2. ### Claim 7 (depends on 6) The method of claim 6, further comprising analyzing the change in quantified levels over time to perform one or more selected from the group consisting of analyzing response to therapy changes and monitoring disease progression. ### Claim 8 (depends on 6) The method of claim 6, the parameters of the CRT therapy comprising at least one of A-V delay, V-V delay, and stimulation vector. ### Claim 9 (depends on 6) The method of claim 6, the panel of biomarkers further including at least one additional biomarker selected from the group consisting of SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, MMP-2, MMP-9, and TIMP-4. ### Claim 10 (depends on 6) The method of claim 6, further comprising providing an alert notice to a clinician regarding changes in parameters of CRT therapy. ### Claim 11 A method of treating a patient with CRT therapy comprising: selecting a patient exhibiting heart failure symptoms and lacking a CRT device; quantifying levels of a panel of biomarkers in a biological sample of the patient; analyzing the quantified levels to determine response to CRT therapy with an external medical device comprising a microprocessor, wherein the microprocessor analyzes the quantified levels comprising comparing quantified levels to threshold levels to determine likelihood of response to CRT therapy; and places the patient into one of a set of categories using the quantified levels, the set of categories including at least one of CRT therapy responders, CRT therapy non-responders, and indeterminate response; treating the patient with a CRT device if the patient is in the CRT therapy responders category; the panel of biomarkers comprising at least CRP, sST2, TIMP-1, and TIMP-2.