# US 10,502,689 B2 · Portable reader module, portable reader, and method for quantitative analysis of an assay > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,502,689 B2 - Document ID: US10502689B2 - Status: Granted - Kind: B2 - Application number: 15/873,164 - Filed: 2018-01-17 - Published: 2018-05-24 - Granted: 2019-12-10 - Earliest claimed: 2013-03-21 - Assignees: MicroDiscovery GmbH - Applicants: MicroDiscovery GmbH - Inventors: Dieter Beule; Johannes Schuchhardt; Arif Malik - Web page: https://patentgrep.com/patent/US10502689B2 ## CPC - G01N 21/8483: {Investigating reagent band (test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04)} - G01N 33/5017: {for testing neoplastic activity} - G06T 2207/10024: Color image - G06T 2207/30004: Biomedical image processing - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL ## Abstract A portable reader module includes a housing, a first receptacle configured to removably receive a portable device having an imager, and a second receptacle configured to removably receive a cartridge. The first receptacle includes a first optical entrance for the imager to the internal space of the housing. The second receptacle includes a second optical entrance to the internal space of the housing. A light-deflecting optical element is arranged within the internal space of the housing to define an optical path between the first optical entrance and the second optical entrance. An illuminating path for illuminating the cartridge is defined in the housing. The housing is configured to allow the internal space to be light-shielded. ## Claims ### Claim 1 A portable reader, comprising: a portable reader module comprising: a housing comprising an internal space, a first receptacle configured to removably receive a portable device comprising a lens, an imager, a central processing unit, and a display, the first receptacle comprising a first optical entrance for the imager to the internal space of the housing, and a second receptacle configured to removably receive a cartridge including at least one test zone, the second receptacle comprising a second optical entrance to the internal space of the housing so that the cartridge is visible to and from the internal space; a first optical reference element comprising at least one of a positional reference, intensity references and colour references, and configured to allow at least one of calibration and self-testing of the portable device, wherein the first optical reference element is arranged inside of the second receptacle separate to the cartridge or in the housing separate to the cartridge; a light-deflecting optical element arranged within the internal space of the housing to define an optical path between the first optical entrance and the second optical entrance; and an illuminating path for illuminating the cartridge defined in the housing; wherein the housing is configured to allow the internal space to be light-shielded, wherein the portable device can be received in the first receptacle of the housing, and wherein the portable device is operable to capture an image of the cartridge including the at least one test zone and of the first optical reference element when the cartridge is received in the second receptacle of the housing, to process the captured image, and to display a test result. ### Claim 2 (depends on 1) The portable reader according to claim 1, wherein the second optical entrance is in a field of view of the imager. ### Claim 3 (depends on 1) The portable reader according to claim 1, further comprising an adapter for holding the cartridge, wherein the adapter for holding the cartridge comprises a cartridge interface which is inserted into the second receptacle, and a cartridge holder for holding the cartridge, wherein the cartridge holder cooperates with the cartridge interface when the cartridge holder is releasably attached to the cartridge interface. ### Claim 4 (depends on 3) The portable reader according to claim 3, wherein one of the cartridge holder and cartridge interface comprises magnetic bodies and the other one of the cartridge holder and the cartridge interface comprises metal pins or discs which cooperate together with the magnetic bodies to hold the cartridge holder in place relative to the cartridge interface. ### Claim 5 (depends on 1) The portable reader according to claim 1, further comprising one or more identification marks uniquely identifying at least one individual component or part of the portable reader module. ### Claim 6 (depends on 1) The portable reader according to claim 1, wherein the portable device comprises a light source, and wherein the illuminating path comprises a reflector for reflecting light from the light source to the cartridge. ### Claim 7 (depends on 1) The portable reader according to claim 1, further comprising a second optical reference element configured to allow at least one of calibration and self-testing of the portable device, the second optical reference element being differing from the first optical reference element in at least one of pattern, greyscale, and colour. ### Claim 8 (depends on 1) The portable reader according to claim 1, wherein the second receptacle is configured to be placeable, with our without an inserted cartridge, onto a surface so that the portable device is in a substantially upright position relative to the surface. ### Claim 9 (depends on 1) The portable reader module according to claim 1, wherein at least one of the first receptacle and the second receptacle comprises holders for retaining the portable device in the first receptacle and the cartridge in the second receptacle. ### Claim 10 (depends on 1) The portable reader according to claim 1, further comprising an adjustment element arranged in the housing, the adjustment element being configured to adjust at least one of the location and orientation of the light-deflecting optical element. ### Claim 11 (depends on 1) The portable reader according to claim 1, wherein the first receptacle comprises a bottom element which is removably attached to the housing and which comprises a holder to hold the light-deflecting optical element in the internal space. ### Claim 12 (depends on 1) The portable reader according to claim 1, wherein at least portions of the internal space are provided with a low-reflection surface. ### Claim 13 (depends on 1) The portable reader according to claim 1, wherein the light-deflecting optical element comprises a mirror or a prism. ### Claim 14 (depends on 1) The portable reader according to claim 1, wherein the housing further comprises an opening which allows access to the internal space, and wherein the first receptacle comprises a bottom element which is removably attached to the housing, which closes the opening and which comprises a holder to hold the light-deflecting optical element in the internal space. ### Claim 15 (depends on 1) The portable reader module according to claim 1, wherein the positional reference comprises at least one of crosses, lines, and checker boards, wherein the intensity references comprises at least one of grey scales, grey step wedges, checker broads, line pattern and noise pattern, and/or wherein the colour references comprises at least one of colour scales, colour step wedges, gratings and a prism. ### Claim 16 (depends on 3) The portable reader module according to claim 3, wherein the cartridge holder comprises at least one of an open cavity for accommodating the cartridge aligned with respect to the cartridge holder and adjusting elements provided in the cavity and engaging with the cartridge when placed into the cartridge holder. ### Claim 17 (depends on 14) The portable reader module according to claim 14, wherein the holder is formed like a housing over the first optical entrance for shielding the light-deflecting optical element and the first optical entrance from light emanating from the light source. ### Claim 18 Using of a portable reader, comprising: a portable reader module comprising a housing comprising an internal space, a first optical reference element comprising at least one of a positional reference, intensity references and color references, a first receptacle configured to removably receive a portable device comprising an imager, the first receptacle comprising a first optical entrance for the imager to the internal space of the housing, and a second receptacle configured to removably receive a cartridge, the second receptacle comprising a second optical entrance to the internal space of the housing so that the cartridge is visible to and from the internal space, wherein the first optical reference element is arranged inside of the second receptacle separate to the cartridge or in the housing separate to the cartridge; a light-deflecting optical element arranged within the internal space of the housing to define an optical path between the first optical entrance and the second optical entrance; and an illuminating path for illuminating the cartridge defined in the housing; wherein the housing is configured to allow the internal space to be light-shielded; and a portable device received in the first receptacle of the housing, the portable device comprising an imager, a processing unit, and a display, for capturing with the imager an image of a cartridge including at least one test zone and of the first optical reference element when the cartridge is received in the second receptacle of the housing, for processing the captured image with the processing unit, and for displaying a test result on the display.