# US 10,502,688 B2 · Identification and analysis of materials and molecular structures

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- Number: US 10,502,688 B2
- Document ID: US10502688B2
- Status: Granted
- Kind: B2
- Application number: 15/464,114
- Filed: 2017-03-20
- Published: 2017-07-06
- Granted: 2019-12-10
- Earliest claimed: 2013-10-02
- Assignees: Ondax, Inc.
- Applicants: Ondax, Inc.
- Inventors: James Carriere; Lawrence Ho; Frank Havermeyer; Eric Maye; Randy Heyler
- Web page: https://patentgrep.com/patent/US10502688B2

## CPC

- G01N 21/65: Raman scattering
- G01N 21/3581: using far infrared light; using Terahertz radiation
- G01N 2201/06113: Coherent sources; lasers
- G01N 2201/068: Optics, miscellaneous
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Provided are methods and systems for identification and analysis of materials and molecular structures. An apparatus for identification and analysis of materials and molecular structures may include a laser. The laser may, in turn, include an amplified spontaneous emission-suppressed single-frequency laser excitation source. The apparatus may further comprise a plurality of filters. The plurality of filters may include reflective volume holographic grating blocking filters. The apparatus may also comprise an optical unit and an optical spectrometer. The optical unit may be configured to deliver excitation energy to a sample substance and capture Raman signal scattering from the sample substance. The optical spectrometer may be disposed in a path of the Raman signal and configured to measure a spectrum of the Raman signal and generate a detection signal. Finally, the apparatus may comprise a processing unit configured to analyze the spectrum.

## Claims

### Claim 1

A method for identification and analysis of materials and molecular structures comprising:
providing a laser excitation source;
providing a plurality of filters, the plurality of filters including at least one reflective blocking filter with a transition width of <50 cm−1;
providing at least one optical unit delivering excitation energy to a sample substance and capturing a Raman signal scattering from the sample substance, the captured Raman signal being at least in a spectral range of +20 cm−1 to +200 cm−1 or −20 cm−1 to −200 cm−1;
providing an optical spectrometer disposed in a path of the Raman signal, the optical spectrometer measuring a spectrum of the Raman signal and generating a detection signal, the optical spectrometer collecting low-frequency Stokes or anti-Stokes Raman spectra, the low-frequency Stokes or anti-Stokes Raman spectra being in a +20 cm−1 to +200 cm−1 or −20 cm−1 to −200 cm−1 Raman spectrum; and
providing a processing unit configured to analyze the captured Raman signal within the +20 cm−1 to +200 cm−1 or −20 cm−1 to −200 cm−1 portion of a spectrum of the sample substance, the analyzing of the +20 cm−1 to +200 cm−1 or −20 cm−1 to −200 cm−1 portion of the spectrum of the sample substance including measuring changes to at least one of peak shape and peak locations associated with structural characteristics or changes in form.

### Claim 2 (depends on 1)

The method of claim 1 further comprising:
adding complementary components of the low-frequency Stokes or anti-Stokes Raman spectra to boost an overall signal, the optical spectrometer measuring a spectrum of the overall signal.

### Claim 3 (depends on 1)

The method of claim 1, wherein the at least one reflective blocking filter has a cumulative optical density of at least 4.

### Claim 4 (depends on 1)

The method of claim 1, wherein the laser excitation source is an ASE-suppressed laser.

### Claim 5 (depends on 1)

The method of claim 1, wherein the optical spectrometer further collects Raman spectra in a fingerprint region.

### Claim 6 (depends on 1)

The method of claim 1, wherein the sample substance includes at least one of a polymorphic, polyamorphous, allotropic, isomeric, isotopologous, cocrystalline, enantiomeric, polymeric, crystalline, and conformational element, compound, or substance.

### Claim 7 (depends on 1)

The method of claim 1, wherein the sample substance includes at least one of a pharmaceutical or biopharmaceutical compound, an explosive agent, a biological substance, a cellular substance, a chemically hazardous substance, a radiological substance, a mineralogical substance, a nuclear material, a radiological material, a semiconductor material, a photovoltaic material, a polymer material, and an electronic material.

### Claim 8 (depends on 1)

The method of claim 1, wherein the structural characteristics and/or changes in form include at least one of: phonon vibrational modes; polymorphic, allotropic, isomeric, conformational, isotopologic, or cocrystalline forms; amorphous and crystalline phases and phase changes; crystalline orientation; cocrystalline composition; rotational modes; physical properties; temperature; strain or defects; methods of manufacture; and environmental exposure.

### Claim 9 (depends on 1)

The method of claim 1, wherein the laser excitation source, the plurality of filters, and the optical spectrometer are individual units optically coupled to each other.

### Claim 10 (depends on 1)

The method of claim 1, wherein the laser excitation source and the plurality of filters are optically coupled to the optical spectrometer as a single unit.

### Claim 11 (depends on 1)

The method of claim 1, wherein the laser excitation source, the plurality of filters, and the optical spectrometer are a single unit.

### Claim 12 (depends on 1)

The method of claim 1, wherein the plurality of filters and the optical spectrometer are a single unit and the laser excitation source is optically coupled to the single unit.

### Claim 13 (depends on 1)

The method of claim 1, wherein the optical spectrometer selects at least one of a peak and a signal in the spectrum of the Raman signal in the +20 cm−1 to +200 cm−1 or −20 cm−1 to −200 cm−1 portion, the at least one of the peak and the signal being associated with at least one material, compound, and molecular form, the processing unit determining at least one of a presence, an absence, and a concentration of the at least one material, compound, and molecular form using the at least one of the peak and the signal.

### Claim 14 (depends on 13)

The method of claim 13, wherein the processing unit comprises a computer.

### Claim 15 (depends on 1)

The method of claim 1, wherein the transition width is at least one of a separation from a 50% transmission point to a wavelength of the excitation energy and a separation from the 50% transmission point to a 0 cm−1 reference point of the spectrum of the Raman signal.