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AssigneeIndiana University Research and Technology Corporation
InventorsTrevor Douglas, Benjamin Harold Schwarz, Ranjit Koliyatt, Masaki Uchida, John Alexander Avera
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The invention provides a fusion protein comprising an antigen binding domain linked to a bacteriophage decoration (Dec) protein along with a polynucleotide comprising the nucleic acid sequence of the fusion protein and a vector comprising the polynucleotide. Additionally, the invention provides a composition comprising the fusion protein and a virus-like particle (VLP), and a method of treating a disease in a mammal comprising administering a therapeutically effective amount of the composition to the mammal. The invention also provides a method of vaccinating against a disease comprising administering a composition comprising the fusion protein and a VLP encapsulating a protein.
A fusion protein comprising an antigen binding domain of a trimerizable tumor necrosis factor super family (TNFSF) protein, and the fusion protein further comprising a trimerizable double stranded DNA bacteriophage decoration (Dec) accessory coat protein.
A fusion protein comprising an antigen binding domain of a trimerizable tumor necrosis factor super family (TNFSF) protein, the fusion protein further comprising a trimerizable double stranded DNA bacteriophage decoration (Dec) accessory coat protein, and wherein the TNFSF protein is selected from the group consisting of:
A fusion protein comprising an antigen binding domain of a trimerizable tumor necrosis factor super family (TNFSF) protein, and the fusion protein further comprising a trimerizable double stranded DNA bacteriophage decoration (Dec) accessory coat protein, wherein the TNFSF protein is CD40L.
Dependencies are inferred from the claim text.