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US 10,501,629 B2Granted
Process for the preparation of isosulfan blue
AssigneeDishman Carbogen Amcis Limited
InventorsJanmejay Rajnikant Vyas, Yashbir Singh, Chiragkumar Chandrakantbhai Patel, Sandip Babanrao Pawar, Himani Dhotre, K. Narasimha Sarma, Dilip N. Patel, Renish Ghetiya, Babulal R. Patel, Sarika P. Deshmukh, Girish Mavada
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Abstract
The present invention relates to process for preparation of Isosulfan blue (Formula I) substantially free from desethyl impurity.
Claims26
A process for preparation of Isosulfan blue having Formula I, substantially free of desethyl impurity, wherein
- the process comprises steps of:
- a) oxidizing isoleuco acid by an oxidizing agent in a solvent;
- b) treating isosulfan blue of step (a) with water and hydrochloric acid to provide isosulfan blue hydrochloric acid salt;
- c) treating Isosulfan blue hydrochloric acid salt of step (b) with water and an inorganic salt to provide crude isosulfan blue;
- d) treating crude isosulfan blue of step (c) with water and an inorganic or an organic salt.
2 more elements
Dependencies are inferred from the claim text.