Anti-B7-H3 antibodies and diagnostic uses thereof
AssigneeSpring BioScience Corporation
InventorsFernando Jose Rebelo do Couto, Zhiming Liao, Yifei Zhu
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Abstract
Provided herein are B7-H3 antibodies, fragments of such antibodies, and compositions comprising the same. The antibodies, antibody fragments and compositions are useful in a number of analytical methods, including immunohistochemical and immunocytochemical detection and analysis of B7-H3. Also provided herein are isolated peptides, compositions, and fusion proteins containing immunogenic determinants for said B7-H3 antibodies, animals immunized with the peptides and fusion proteins, isolated B cells obtained from the animals, and hybridomas made from the isolated B cells.
Claims24
An isolated antibody or an antigen binding fragment thereof, said antibody or antigen-binding fragment thereof comprising a heavy chain (HC) immunoglobulin variable domain sequence and a light chain (LC) immunoglobulin variable domain sequence, wherein the antibody binds to an epitope of human B7-H3 comprising the amino acid sequence KHSDSKEDDGQEIA (SEQ ID NO:
- 1), wherein:
- (a) the HC comprises a CDR3 sequence of RAPVVSTSMTFNI (SEQ ID NO:
- 4) or TVVGGWGYALDL (SEQ ID NO:
- 10);
- or
- (b) the LC comprises a CDR3 sequence QGEFTCSGADCGA (SEQ ID NO:
- 7);
- or
- (c) the HC comprises a CDR3 sequence of RAPVVSTSMTFNI (SEQ ID NO:
- 4) or TVVGGWGYALDL (SEQ ID NO:
- 10), and wherein the LC comprises a CDR3 sequence QGEFTCSGADCGA (SEQ ID NO:
- 7).
Dependencies are inferred from the claim text.