# US 10,501,535 B2 · Antibody targeting stem cell factor

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- Number: US 10,501,535 B2
- Document ID: US10501535B2
- Status: Granted
- Kind: B2
- Application number: 15/163,391
- Filed: 2016-05-24
- Published: 2016-09-08
- Granted: 2019-12-10
- Earliest claimed: 2011-01-10
- Assignees: The Regents of the University of Michigan
- Applicants: The Regents of the University of Michigan
- Inventors: Nicholas W. Lukacs; Steven L. Kunkel; Cory Hogaboam
- Web page: https://patentgrep.com/patent/US10501535B2

## CPC

- C07K 16/24: against cytokines, lymphokines or interferons
- C07K 2317/52: Constant or Fc region; Isotype
- C07K 2317/56: variable (Fv) region, i.e. VH and/or VL
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.

## Claims

### Claim 1

An isolated recombinant monoclonal anti-stem cell factor (SCF) antibody comprising:
(a) a light chain variable domain comprising an amino acid sequence comprising:
(i) a first amino acid sequence comprising the CDR1 sequence provided by amino acids 42-53 of SEQ ID NO: 4;
a second amino acid sequence comprising the CDR2 sequence provided by amino acids 69-79 of SEQ ID NO: 4; and
(iii) a third amino acid sequence comprising the CDR3 sequence provided by amino acids 112-124 of SEQ ID NO: 4; and
(b) a heavy chain variable domain comprising an amino acid sequence comprising:
(i) a first amino acid sequence comprising the CDR1 sequence provided by amino acids 45-56 of SEQ ID NO: 2;
a second amino acid sequence comprising the CDR2 sequence provided by amino acids 71-86 of SEQ ID NO: 2; and
(iii) a third amino acid sequence comprising the CDR3 sequence provided by amino acids 119-123 of SEQ ID NO: 2.

### Claim 2 (depends on 1)

The antibody of claim 1, wherein the antibody is a humanized antibody.

### Claim 3 (depends on 1)

The antibody of claim 1, wherein the antibody is a chimeric antibody.

### Claim 4 (depends on 1)

The antibody of claim 1, wherein the antibody is monovalent and comprises an Fc region.

### Claim 5 (depends on 1)

The antibody of claim 1, wherein the antibody is bivalent or bispecific.

### Claim 6 (depends on 1)

The antibody of claim 1, wherein the antibody is an antibody fragment selected from the group consisting of a Fab, a Fab′-SH, an Fv, an scFv, and a (Fab′)2.

### Claim 7 (depends on 1)

The antibody of claim 1, wherein the antibody comprises a single Fab region linked to an Fc region.