Nepovirus coat protein fusion polypeptides and their use
AssigneesCentre National De La Recherche Scientifique, Universite De Strasbourg, Institut National de la Recherche Agronomique
InventorsLorene Belval, Gerard Demangeat, Caroline Hemmer, Christophe Ritzenthaler
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Abstract
The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from nepoviruses, virus-like particles made with such proteins, and the uses thereof. The particles of the invention can expose and/or encage molecules of interest and have utility in various fields such as the pharmaceutical, agro, or veterinary areas.
Claims19
A virus-like particle comprising a nepovirus coat protein fused to a compound, wherein the compound is fused to the N-terminus of the nepovirus coat protein and the nepovirus coat protein is a grapevine fanleaf virus (GFLV) coat protein.
A molecule comprising a nepovirus GFLV coat protein fused to a compound, wherein the compound is fused to the N-terminus of the nepovirus GFLV coat protein and the nepovirus GFLV coat protein comprises SEQ ID NO:
- 1.
A method of producing virus-like particles comprising (i) providing a nepovirus GFLV coat protein comprising SEQ ID NO:
- 1 that is N-terminally fused to a compound, and (ii) allowing said protein, alone or in mixture with other proteins, to assemble into the virus-like particles.
Dependencies are inferred from the claim text.