# US 10,501,494 B2 · Uses of peptides to treat brain injury and disease

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- Number: US 10,501,494 B2
- Document ID: US10501494B2
- Status: Granted
- Kind: B2
- Application number: 14/263,347
- Filed: 2014-04-28
- Published: 2014-10-30
- Granted: 2019-12-10
- Earliest claimed: 2013-04-26
- Assignees: Creative Bio-Peptides Inc.
- Applicants: Michael Ruff
- Inventors: Michael Ruff
- Web page: https://patentgrep.com/patent/US10501494B2

## CPC

- C07K 7/08: having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68)
- C07K 7/06: having 5 to 11 amino acids
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

A method of treating loss of brain function in a patient comprising the steps of preparing a composition comprising a D peptide and a pharmaceutically acceptable carrier. The D peptide has the general structure: A-B-C-D-E-F-G-H in which A is Ala, or absent, B is Ser, Thr or absent, C is Ser, Thr or absent, D is Ser, Thr, Asn, Glu, Arg, Ile, Leu, E is Ser, Thr, Asp, Asn, F is Thr, Ser, Asn, Arg, Gln, Lys, Trp, G is Tyr, and H is Thr, Ser, Arg, Gly. All amino acids in the D peptide are the D stereoisomeric configuration. The peptide composition is administered in a therapeutically effective dose.

## Claims

### Claim 1

A method of treating brain trauma in a patient comprising the steps of: preparing a composition comprising a D peptide and a pharmaceutically acceptable carrier, said D peptide further comprises at most twenty (20) D amino acid residues in length and contains five contiguous D amino acid residues having the sequence Thr-Thr-Asn-Tyr-Thr (SEQ ID NO: 2), and administering said composition to the patient in a therapeutically effective dose, wherein said composition acts to treat the brain trauma in the patient, and wherein said brain trauma is traumatic brain injury.

### Claim 2 (depends on 1)

The method as defined in claim 1 wherein said administering of said composition to the patient is selected from the group consisting of administering: orally, bucally, parenterally, topically, rectally, vaginally, by intranasal inhalation spray or by intrapulmonary inhalation.

### Claim 3 (depends on 1)

The method as defined in claim 1 further comprising, said D peptide is at most twelve (12) D amino acid residues in length.

### Claim 4 (depends on 1)

The method as defined in claim 1 further comprising, said D peptide is at most eight (8) D amino acid residues in length.

### Claim 5 (depends on 1)

The method as defined in claim 1 further comprising, said D peptide is five (5) D amino acid residues in length.