# US 10,501,479 B2 · Benzenesulfonyl-asymmetric ureas and medical uses thereof

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- Number: US 10,501,479 B2
- Document ID: US10501479B2
- Status: Granted
- Kind: B2
- Application number: 15/464,430
- Filed: 2017-03-21
- Published: 2017-09-28
- Granted: 2019-12-10
- Earliest claimed: 2016-03-22
- Assignees: Helsinn Healthcare SA
- Applicants: Helsinn Healthcare SA
- Inventors: Claudio Giuliano; Antoine Daina; Claudio Pietra
- Web page: https://patentgrep.com/patent/US10501479B2

## CPC

- C07D 513/04: Ortho-condensed systems
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 25/30: for treating abuse or dependence
- A61P 25/32: Alcohol-abuse
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07C 311/47: Y being a hetero atom
- C07C 317/14: having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
- C07C 317/26: having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C 317/42: Y being a hetero atom
- C07C 317/44: having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07D 209/04: Indoles; Hydrogenated indoles
- C07D 209/08: with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C07D 209/44: Iso-indoles; Hydrogenated iso-indoles
- C07D 213/34: to which a second hetero atom is attached
- C07D 213/76: to which a second hetero atom is attached (nitro radicals C07D213/61)
- C07D 215/06: having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
- C07D 215/08: with acylated ring nitrogen atom
- C07D 215/10: Quaternary compounds
- C07D 215/58: with hetero atoms directly attached to the ring nitrogen atom
- C07D 217/04: with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C07D 217/10: Quaternary compounds
- C07D 223/16: Benzazepines; Hydrogenated benzazepines
- C07D 231/56: Benzopyrazoles; Hydrogenated benzopyrazoles
- C07D 233/64: with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C07D 235/14: Radicals substituted by nitrogen atoms (by nitro radicals C07D235/10)
- C07D 237/20: Nitrogen atoms (nitro radicals C07D237/12)
- C07D 239/26: with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D 239/48: Two nitrogen atoms
- C07D 241/04: having no double bonds between ring members or between ring members and non-ring members
- C07D 241/12: with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D 295/088: to an acyclic saturated chain
- C07D 307/87: Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D 311/76: Benzo[c]pyrans
- C07D 317/34: Oxygen atoms
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07D 405/04: directly linked by a ring-member-to-ring-member bond
- C07D 405/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 409/12: linked by a chain containing hetero atoms as chain links
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D 417/10: linked by a carbon chain containing aromatic rings
- C07D 417/12: linked by a chain containing hetero atoms as chain links
- C07D 471/04: Ortho-condensed systems
- C07D 471/08: Bridged systems
- C07D 487/04: Ortho-condensed systems
- C07D 495/04: Ortho-condensed systems
- C07C 2601/02: with a three-membered ring
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.

## Claims

### Claim 1

A compound of Formula IV:
or a pharmaceutically acceptable salt thereof, wherein:
a dashed line indicates an optional bond;
X is a bond, CO, or CR7R8;
k is 0-2;
R1 and R2 are each independently, H, C1-3 alkyl, methoxy, halo or OH;
or R1 and R2 taken together with the atoms to which they are attached form a 5-6 membered ring;
or R1 and X taken together with the atoms to which they are attached form a 5-6 membered ring;
R3 is H, C1-3 alkyl, methoxy, halo, OH, COOR12, CR13R14OH, COHNR15, cycloalkyl, or heteroaryl;
R4 is a bond, NR6 or CR9R10;
or R3 and R4 taken together with the atoms to which they are attached form a 3-6-membered ring;
R6 is a bond, H, or CH3;
R7 and R8 are each, independently, H or C1-3 alkyl, or CONH2, wherein said C 1-3 alkyl is optionally substituted with halo;
R9 and Rl0 are each, independently, H or C1-3 alkyl, wherein said C1-3 alkyl is optionally substituted with halo;
R12 is H or C1-3 alkyl;
R13 and R14 are each independently H or C1-3 alkyl;
R15 is H or C1-3 alkyl;
U is C, N, S, or 0;
Z is halo or methoxy;
R′ is a halo, heteroaryl, C1-6 alkoxy, C1-6 alkyl, heterocycloalkyl, CN cycloalkyl, CO2(C1-6alkyl), or CO(C1-6 alkyl);
or two R′ taken together with the atoms to which they are attached form a 5-6-membered ring;
R16 is H or C1-3 alkyl;
R17 is H, halo, or C1-3 alkyl;
1 is 0-3;
m is 0-3;
n is 0-3; and
p is 1-3.

### Claim 2 (depends on 1)

The compound of claim 1, wherein X is CO.

### Claim 3 (depends on 1)

The compound of claim 1, wherein X is a bond.

### Claim 4 (depends on 1)

The compound of claim 1, wherein said X is C1-3 alkyl.

### Claim 5 (depends on 1)

The compound of claim 1, wherein X is CH(CH3).

### Claim 6 (depends on 1)

The compound of claim 1, wherein X is C(CH3)2.

### Claim 7 (depends on 1)

The compound of claim 1, wherein X is CHCF3.

### Claim 8 (depends on 1)

The compound of claim 1, wherein X is CH(CH2CH3).

### Claim 9 (depends on 1)

The compound of claim 1, wherein X is C1-3 alkyl substituted with halo.

### Claim 10 (depends on 1)

The compound of claim 1, wherein
is selected from the group consisting of

### Claim 11 (depends on 1)

The compound of claim 1, wherein
is phenyl.

### Claim 12 (depends on 1)

The compound of claim 1, wherein R1 is OH.

### Claim 13 (depends on 1)

The compound of claim 1, wherein R1 is CH3.

### Claim 14 (depends on 1)

The compound of claim 1, wherein R2 is CH3.

### Claim 15 (depends on 1)

The compound of claim 1, wherein R3 is F.

### Claim 16 (depends on 1)

The compound of claim 1, wherein R3 is Cl.

### Claim 17 (depends on 1)

The compound of claim 1, wherein R3 is methoxy.

### Claim 18 (depends on 1)

The compound of claim 1, wherein R4 is CR9R10.

### Claim 19 (depends on 1)

The compound of claim 1, wherein R4 is CH2.

### Claim 20 (depends on 1)

The compound of claim 1, wherein R4 is CHCH3 .

### Claim 21 (depends on 1)

The compound of claim 1, wherein R4 is C(CH3)2.

### Claim 22 (depends on 1)

The compound of claim 1, wherein R4 is NCH3.

### Claim 23 (depends on 1)

The compound of claim 1, wherein R4 and R3 come together to form a 5-membered heterocyclic ring.

### Claim 24 (depends on 1)

The compound of claim 1, wherein
is selected from the group consisting of

### Claim 25 (depends on 1)

The compound of claim 1, wherein
is

### Claim 26 (depends on 1)

The compound of claim 1, wherein
is
optionally substituted with 1-2 substituents from the group consisting of CH3, CH2CH3, and F.

### Claim 27 (depends on 1)

The compound of claim 1, wherein
is tetrahydroisoquinoline.

### Claim 28 (depends on 1)

The compound of claim 1, wherein
is tetrahydroisoquinoline substituted with 1-3 substituents from the group consisting of CH3, CH2CH3, F, and methoxy.

### Claim 29 (depends on 1)

The compound of claim 1, wherein
is selected from the group consisting of

### Claim 30 (depends on 1)

The compound of claim 1, wherein p is 1.

### Claim 31 (depends on 1)

The compound of claim 1, wherein p is 2.

### Claim 32 (depends on 1)

The compound of claim 1, wherein n is 0.

### Claim 33

A compound or a pharmaceutically acceptable salt thereof selected from the group consisting of:
Compound
No.
Chemical Structure
Chemical Name
H0990
(S)-4-(3-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)ureido)-N- (1H-indol-5-yl)benzenesulfonamide
H0991
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N-(1H- indol-5-yl)benzenesulfonamide
H0997
(S)-4-(3-(1-(2,3-dichloro-4-(pyrazin- 2-yl)phenyl)ethyl)ureido)-N-(1H- indol-5-yl)benzenesulfonamide
H1003
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N- (1,2,3,4-tetrahydroquinolin-6- yl)benzenesulfonamide
H1004
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N- (1,2,3,4-tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1005
(S)-4-(3-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)ureido)-N- (1,2,3,4-tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1006
(S)-4-(3-(1-(2,3-dichloro-4-(pyrazin- 2-yl)phenyl)ethyl)ureido)-N- (1,2,3,4-tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1008
(S)-4-(3-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)ureido)-N- (1,2,3,4-tetrahydroquinolin-6- yl)benzenesulfonamide
H1017
(S)-4-(3-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)ureido)-N-(2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1018
(S)-4-(3-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)ureido)-N-(2- ethyl-1,2,3,4-tetrahydroisoquinolin- 6-yl)benzenesulfonamide
H1024
(S)-1-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)-3-(4- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1025
(S)-1-(4-(((2-acetyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- (2,3-dichloro-4- methoxyphenyl)ethyl)urea
H1026
(S)-1-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)-3-(4-(((2- (methylsulfonyl)-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1027
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1028
(S)-1-(1-phenylethyl)-3-(4- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1029
1-benzyl-3-(4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1033
(S)-4-(3-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)ureido)-N-(2- (methylsulfonyl)-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1034
(S)-N-(2-acetyl-1,2,3,4- tetrahydroisoquinolin-6-yl)-4-(3-(1- (2,3-dichloro-4- methoxyphenyl)ethyl)ureido) benzenesulfonamide
H1038
l-(3-chlorobenzyl)-3-(4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1039
1-(2-chlorobenzyl)-3-(4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1040
1-(2,3-dichlorobenzyl)-3-(4- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1041
1-(1-(2-chlorophenyl)ethyl)-3-(4- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1042
1-(1-(3-chlorophenyl)ethyl)-3-(4- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1043
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((1,2,3,4- tetrahydroisoquinolin-7- yl)methyl)sulfonyl)phenyl)urea
H1044
1-(2,3-dichlorobenzyl)-3-(4- (((1,2,3,4-tetrahydroisoquinolin-7- yl)methyl)sulfonyl)phenyl)urea
H1045
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-((indolin-6- ylmethyl)sulfonyl)phenyl)urea
H1046
1-(2,3-dichlorobenzyl)-3-(4- ((indolin-6- ylmethyl)sulfonyl)phenyl)urea
H1047
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-((indolin-5- ylmethyl)sulfonyl)phenyl)urea
H1048
1-(2,3-dichlorobenzyl)-3-(4- ((indolin-5- ylmethyl)sulfonyl)phenyl)urea
H1049
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N- (1,2,3,4-tetrahydroisoquinolin-7- yl)benzenesulfonamide
H1054
ethyl (S)-6-((4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)phenyl) sulfonamido)-3,4- dihydroisoquinoline-2(1H)- carboxylate
H1055
ethyl (S)-6-(((4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)phenyl) sulfonyl)methyl)-3,4- dihydroisoquinoline-2(1H)- carboxylate
H1056
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1057
1-(2,3-dichlorobenzyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1067
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((2-((5-methyl-2-oxo-1,3- dioxol-4-yl)methyl)-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1068
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N-(2- ((5-methyl-2-oxo-1,3-dioxol-4- yl)methyl)-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1071
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1072
(S)-1-(4-(((2-benzyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- (2,3-dichlorophenyl)ethyl)urea
H1080
1-((S)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-((1-(1,2,3,4- tetrahydroisoquinolin-6- yl)ethyl)sulfonyl)phenyl)urea
H1081
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-((2-(1,2,3,4- tetrahydroisoquinolin-6-yl)propan-2- yl)sulfonyl)phenyl)urea
H1092
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-((isochroman-6- ylmethyl)sulfonyl)phenyl)urea
H1097
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-((isochroman-7- ylmethyl)sulfonyl)phenyl)urea
H1098
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((1,3-dihydroisobenzofuran-5- yl)methyl)sulfonyl)phenyl)urea
H1102
1-((S)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-((1-(1,2,3,4- tetrahydroisoquinolin-6- yl)ethyl)sulfonyl)phenyl)urea hydrochloride
H1103
1-((S)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-((1-(1,2,3,4- tetrahydroisoquinolin-6- yl)ethyl)sulfonyl)phenyl)urea hydrochloride
H1106
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N-(1H- indazol-5-yl)benzenesulfonamide
H1111
(S)-N-(1H-benzo[d]imidazol-5-yl)- 4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido) benzenesulfonamide
H1142
(S)-1-(4-(((1H-indol-5- yl)methyl)sulfonyl)phenyl)-3-(1- (2,3-dichlorophenyl)ethyl)urea
H1148
1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1156
N-(isoindolin-5-yl)-4-(3-(1- phenylethyl)ureido) benzenesulfonamide
H1179
1-benzyl-3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1188
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)-1- hydroxyureido)-N-(isoindolin-5- yl)benzenesulfonamide
H1190
1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3- phenylurea
H1193
1-benzyl-3-(4-(((2-methylisoindolin- 5-yl)methyl)sulfonyl)phenyl)urea
H1194
1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1199
4-(1-hydroxy-3-(1- phenylethyl)ureido)-N-(isoindolin-5- yl)benzenesulfonamide
H1203
1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(4- methoxybenzyl)urea
H1204
1-benzyl-3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-1- methylurea
H1206
3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-1-methyl- 1-(1-phenylethyl)urea
H1212
1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-((5- methoxypyridin-2-yl)methyl)urea
H1213
1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-1-methyl- 3-(1-phenylethyl)urea
H1214
(R)-1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1215
(S)-1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1219
1-(4-(((2-benzylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1220
1-(4-(((2- (cyclopropylmethyl)isoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1221
1-(4-(((2-ethylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1227
1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(2,2,2- trifluoro-1-phenylethyl)urea
H1231
1-(4-((2-(2-benzylisoindolin-5- yl)propan-2-yl)sulfonyl)phenyl)-3- (1-phenylethyl)urea
H1232
1-(4-((2-(2-ethylisoindolin-5- yl)propan-2-yl)sulfonyl)phenyl)-3- (1-phenylethyl)urea
H1233
1-(4-((1-(2-benzylisoindolin-5- yl)ethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1234
1-(4-((1-(2-ethylisoindolin-5- yl)ethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1235
1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylpropyl)urea
H1248
2-chloro-5-ethyl-N-((4-((isoindolin- 5-ylmethyl)sulfonyl) phenyl)carbamoyl)benzamide
H1249
2-chloro-N-((4-((isoindolin-5- ylmethyl)sulfonyl)phenyl) carbamoyl)- 5-morpholinobenzamide
H1250
2-chloro-N-((4-(N-(isoindolin-5- yl)sulfamoyl)phenyl)carbamoyl)-5- morpholinobenzamide
H1251
2-chloro-5-ethoxy-N-((4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl) carbamoyl)benzamide
H1252
2-chloro-5-ethoxy-N-((4-(N- (isoindolin-5- yl)sulfamoyl)phenyl)carbamoyl) benzamide
H1256
(5-methyl-2-oxo-1,3-dioxol-4- yl)methyl 5-(((4-(3-(1- phenylethyl)ureido)phenyl)sulfonyl) methyl)isoindoline-2-carboxylate
H1259
2-chloro-5-ethyl-N-((4-(N- (isoindolin-5- yl)sulfamoyl)phenyl)carbamoyl) benzamide
H1260
1-(1-(3-chlorophenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1261
1-(1-(2-chlorophenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1262
1-(1-(4-fluorophenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1263
2-chloro-5-ethyl-N-((4-(N-(1,2,3,4- tetrahydroisoquinolin-7- yl)sulfamoyl)phenyl)carbamoyl) benzamide
H1266
1-(1-(3-chlorophenyl)ethyl)-3-(4- (((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1267
1-(1-(2-chlorophenyl)ethyl)-3-(4- (((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1268
1-(1-(4-fluorophenyl)ethyl)-3-(4- (((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1269
1-(1-(3-fluorophenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1272
1-(1-(2-fluorophenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1281
1-(1-(2-chloro-5-ethylphenyl)ethyl)- 3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1283
1-(1-(2-chloro-5- morpholinophenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1284
1-(1-(2-chloro-5- morpholinophenyl)ethyl)-3-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1286
1-1-(2-chloro-5-ethylphenyl)ethyl)- 3-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1291
1-(4-(((3-oxoisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1292
1-(4-(((1-oxoisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1293
1-(4-(((3-hydroxy-2,3-dihydro-1H- inden-5-yl)methyl)sulfonyl)phenyl)- 3-(1-phenylethyl)urea
H1294
1-(1-phenylethyl)-3-(4-(((3- (pyrrolidin-1-yl)-2,3-dihydro-1H- inden-5- yl)methyl)sulfonyl)phenyl)urea
H1298
1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1-(4- methoxyphenyl)ethyl)urea
H1299
(S)-1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1300
(R)-1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1306
(S)-1-(1-phenylethyl)-3-(4- (((2,3,4,5-tetrahydro-1H- benzo[d]azepin-7- yl)methyl)sulfonyl)phenyl)urea
H1308
N-(2-methylisoindolin-5-yl)-4-(3-(1- phenylethyl)ureido) benzenesulfonamide
H1310
4-(1-(3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)ureido) ethyl)phenyl acetate
H1311
(S)-1-(4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-7- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1315
(S)-N-(2-methyl-1,2,3,4- tetrahydroisoquinolin-6-yl)-4-(3-(1- phenylethyl)ureido) benzenesulfonamide
H1316
1-(2-fluoro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1317
1-(2-fluoro-4-(((2-methylisoindolin- 5-yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1319
1-(4-(((2-(oxetan-3-yl)isoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1320
1-(4-(((5,6-dihydro-4H-thieno[2,3- c]pyrrol-2- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1321
1-(4-(((5-methyl-5,6-dihydro-4H- thieno[2,3-c]pyrrol-2- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1322
(S)-1-(4-(((3-methyl-2,3,4,5- tetrahydro-1H-benzo[d]azepin-7- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1323
1-(4-(((6-methyl-6,7-dihydro-5H- pyrrolo[3,4-b]pyridin-3- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1326
1-(1-(3-methoxyphenyl)ethyl)-3-(4- (((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1327
1-(1-(3-methoxyphenyl)ethyl)-3-(4- (((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1329
1-(4-(((2-methyl-2H-indazol-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1333
4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N-(2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1334
4-(3-(1-(2- chlorophenyl)ethyl)ureido)-N-(2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1337
(R)-N-(2-methylisoindolin-5-yl)-4- (3-(1-phenylethyl)ureido) benzenesulfonamide
H1338
1-(4-(((2-(2- methoxyethyl)isoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1339
1-(4-(((2-(cyanomethyl)isoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1340
1-(1-phenylethyl)-3-(4-(((2- (tetrahydrofuran-3-yl)isoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1341
1-(1-phenylethyl)-3-(4-(((2- ((tetrahydrofuran-2- yl)methyl)isoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1342
1-(1-(2-fluorophenyl)ethyl)-3-(4- (((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1343
(R)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1344
1-(1-(2-chlorophenyl)ethyl)-3-(4- (((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1345
1-(1-(2,3-difluorophenyl)ethyl)-3- (4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1346
4-(3-(1-(2,3- difluorophenyl)ethyl)ureido)-N-(2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1347
4-(3-(1-(2- fluorophenyl)ethyl)ureido)-N-(2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1348
(R)-1-(4-(((5-methyl-5,6-dihydro- 4H-thieno[2,3-c]pyrrol-2- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1349
1-(2,3-dichlorobenzyl)-3-(4-(((2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1350
2-methyl-5-(((4-(3-(1- phenylethyl)ureido)phenyl)sulfonyl) methyl)isoindoline 2-oxide
H1351
(R)-1-(4-(((5-methyl-5,6-dihydro- 4H-thieno[2,3-c]pyrrol-3- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1352
(S)-4-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-N-(2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)benzenesulfonamide
H1355
(R)-1-(4-(((7-fluoro-2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethy)urea
H1356
(R)-1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1357
(R)-1-(1-phenylethyl)-3-(4-(((1,1,2- trimethylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1363
(R)-1-(4-(((4-fluoro-2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1366
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((7-fluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1367
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((5-fluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1368
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((7-methoxy-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1369
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((5-methoxy-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1377
1-methyl-1-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1378
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((8-fluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1379
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridin-2- yl)methyl)sulfonyl)phenyl)urea
H1380
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((2,3-dimethyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1381
1-methyl-3-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1382
1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1-(2- methoxyphenyl)ethyl)urea
H1383
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2- methoxyphenyl)-3-(1- phenylethyl)urea
H1384
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((6-methyl-4,5,6,7- tetrahydrothieno[2,3-c]pyridin-2- yl)methyl)sulfonyl)phenyl)urea
H1385
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((7-fluoro-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1386
1-(2-methoxy-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1387
1-(2-methoxy-4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1388
1-(2-methoxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1389
1-(2-fluoro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1-(2- fluorophenyl)ethyl)urea
H1390
1-(2-fluoro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1-(2- methoxyphenyl)ethyl)urea
H1391
1-(1-(2,6-difluorophenyl)ethyl)-3- (4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1392
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((7-methoxy-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfoyl)phenyl)urea
H1393
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2- methoxyphenyl)-3-(1-(2- methoxyphenyl)ethyl)urea
H1394
(R)-1-(4-(((7-fluoroisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1396
(R)-1-(4-(((4-fluoroisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1398
3-(4-((isoindolin-5- ylmethyl)sulfonyl)-2- methoxyphenyl)-1-methyl-1-(1- phenylethyl)urea
H1399
3-(2-fluoro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-1-methyl- 1-(1-phenylethyl)urea
H1400
1-(1-(2,3-dichlorophenyl)ethyl)-3- (2-fluoro-4-(((8-(trifluoromethyl)- 1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1401
1-(1-(2,3-dichlorophenyl)ethyl)-3- (2-fluoro-4-(((3-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1402
1-(1-(2,3-dichlorophenyl)ethyl)-3- (2-fluoro-4-(((3-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-1- methylurea
H1403
1-((S)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((3-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1404
1-(2,6-difluoro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1405
1-(4-(((7-chloroisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1406
1-(4-(((3-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1407
1-(4-(((2,3-dimethyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1408
1-(5-((isoindolin-5- ylmethyl)sulfonyl)pyridin-2-yl)-3- (1-phenylethyl)urea
H1409
3-(4-(((4-fluoroisoindolin-5- yl)methyl)sulfonyl)phenyl)-1- methyl-1-(1-phenylethyl)urea
H1410
1-(1-(2,6-difluorophenyl)ethyl)-3- (4-(((4-fluoroisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1411
1-(1-(2,6-difluorophenyl)ethyl)-3- (2-fluoro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1412
1-(1-(2,6-difluorophenyl)ethyl)-3- (4-((isoindolin-5-ylmethyl)sulfonyl)- 2-methoxyphenyl)urea
H1413
3-(2-methoxy-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-1- methyl-1-(1-phenylethyl)urea
H1414
3-(2-fluoro-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-1- methyl-1-(1-phenylethyl)urea
H1415
1-(1-(2,3-dichlorophenyl)ethyl)-3- (2-methoxy-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1416
1-benzyl-1-methyl-3-(4-(((3-methyl- 1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1417
(R)-1-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)-3-(4-(((2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1420
1-(1-(2-fluorophenyl)ethyl)-3-(4- ((isoindolin-5-ylmethyl)sulfonyl)-2- methoxyphenyl)urea
H1421
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-((isoindolin-5-ylmethyl)sulfonyl)- 2-methoxyphenyl)urea
H1422
(R)-1-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)-3-(2- methoxy-4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1423
(R)-1-(1-(2,3-dichloro-4- methoxyphenyl)ethyl)-3-(2-fluoro-4- (((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1424
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((8-fluoro-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)-2- methoxyphenyl)urea
H1426
1-(1-(2-fluorophenyl)ethyl)-3-(2- methoxy-4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1427
1-(1-(2,3-dichlorophenyl)ethyl)-3- (2-methoxy-4-(((2-methylisoindolin- 5-yl)methyl)sulfonyl)phenyl)urea
H1428
1-(1-(2,3-dichlorophenyl)ethyl)-3- (2-methoxy-4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1429
1-(1-(2,6-difluorophenyl)ethyl)-3- (4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1431
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((2,3-dimethyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)-2- methoxyphenyl)urea
H1436
1-(1-(2,6-difluorophenyl)ethyl)-3- (2-methoxy-4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1437
1-(1-(2,6-difluorophenyl)ethyl)-3- (2-methoxy-4-(((2-methylisoindolin- 5-yl)methyl)sulfonyl)phenyl)urea
H1438
1-(2-methoxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1-(2- methoxyphenyl)ethyl)urea
H1439
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((7-fluoro-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)-2- methoxyphenyl)urea
H1440
1-(4-(((2,3-dimethyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)-2- methoxyphenyl)-3-(1- phenylethyl)urea
H1441
1-(2-methoxy-4-(((3-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1442
1-(2-methoxy-4-(((2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1-(4- methoxyphenyl)ethyl)urea
H1443
1-(1-(2,3-dichlorophenyl)ethyl)-3- (2-methoxy-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-1- methylurea
H1444
1-(1-(3,4-dimethoxyphenyl)ethyl)-3- (4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1445
1-(1-(3,5-difluorophenyl)ethyl)-3- (4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1446
1-(1-(3,5-difluorophenyl)ethyl)-3- (4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1447
1-(2-methyl-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1448
1-(2-hydroxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1449
1-(1-(3,4-dimethoxyphenyl)ethyl)-3- (4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1450
1-(1-(2,6-dimethoxyphenyl)ethyl)-3- (4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1451
1-(1-(2,6-dimethoxyphenyl)ethyl)-3- (4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1454
1-(1-(2-fluoro-6- methoxyphenyl)ethyl)-3-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1455
1-(1-(2-fluoro-6- methoxyphenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1456
1-(2-chloro-4-(((2-methylisoindolin- 5-yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1457
2-(3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)ureido-2- phenylacetamide
H1458
1-hydroxy-1-(4-(((2- methylisoindoIin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1459
methyl 5-((isoindolin-5- ylmethyl)sulfonyl)-2-(3-(1- phenylethyl)ureido)benzoate
H1460
3-(2-hydroxy-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-1-methyl- 1-(1-phenylethyl)urea
H1461
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-3- methoxyphenyl)-3-(1- phenylethyl)urea
H1462
1-(3-methoxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1463
(S)-1-(4-(((5,6-dihydro-4H- pyrrolo[3,4-d]thiazol-2- yl)methyl)sulfonyl)-2- methoxyphenyl)-3-(1- phenylethyl)urea
H1464
(S)-1-(2-methoxy-4-(((5-methyl-5,6- dihydro-4H-pyrrolo[3,4-d]thiazol-2- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1465
(S)-1-(4-(((5,6-dihydro-4H- pyrrolo[3,4-d]thiazol-2- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1466
methyl 5-(((2-methylisoindolin-5- yl)methyl)sulfonyl)-2-(3-(1- phenylethyl)ureido)benzoate
H1467
1-(2-(hydroxymethyl)-4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1468
1-(2-(hydroxymethyl)-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1471
1-hydroxy-3-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1472
1-hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1473
1-hydroxy-1-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1474
3-(2-hydroxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-1- methyl-1-(1-phenylethyl)urea
H1475
1-(1-(3-chloro-4- methoxyphenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1476
1-(1-(3-chloro-4- methoxyphenyl)ethyl)-3-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1477
1-(1-(3-chloro-4- methoxyphenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1478
1-(3-chloro-4-methoxybenzyl)-3-(4- (((2-methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1479
N-(isoindolin-5-yl)-4-(3-(1- phenylethyl)ureido)benzamide
H1480
N-(2-methylisoindolin-5-yl)-4-(3-(1- phenylethyl)ureido)benzamide
H1481
(R)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(2-methoxy-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1482
(S)-1-(1-(2,3-dichlorophenyl)ethyl)- 3-(2-methoxy-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1484
1-(2-cyclopropyl-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1485
1-(2-bromo-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1486
5-((isoindolin-5-ylmethyl)sulfonyl)- 2-(3-(1-phenylethyl)ureido)benzoic acid
H1487
1-(3-hydroxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1490
1-(1-(2-fluorophenyl)ethyl)-1- hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1491
1-(1-(2-fluorophenyl)ethyl)-1- hydroxy-3-(4-(((2-methylisoindolin- 5-yl)methyl)sulfonyl)phenyl)urea
H1492
1-(3-fluoro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1493
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-3-methylphenyl)- 3-(1-phenylethyl)urea
H1494
1-(3-chloro-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1495
1-(1-(2,3-dichlorophenyl)ethyl)-1- hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)-2- methoxyphenyl)urea
H1496
1-(1-(2,3-dichlorophenyl)ethyl)-1- hydroxy-3-(2-methoxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1497
1-(1-(2,3-dichlorophenyl)ethyl)-1- hydroxy-3-(2-methoxy-4-(((1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1498
1-hydroxy-3-(2-methoxy-4- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1499
5-((isoindolin-5-ylmethyl)sulfonyl)- N-methyl-2-(3-(1- phenylethyl)ureido)benzamide
H1500
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2-(oxazol-2- yl)phenyl)-3-(1-phenylethyl)urea
H1501
1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)-2-(oxazol-2- yl)phenyl)-3-(1-phenylethyl)urea
H1502
1-benzyl-1-hydroxy-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1503
1-benzyl-1-hydroxy-3-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1504
1-(3-bromo-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1505
methyl 2-((isoindolin-5- ylmethyl)sulfonyl)-5-(3-(1- phenylethyl)ureido)benzoate
H1506
1-(3-cyclopropyl-4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1507
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-3-(oxazol-2- yl)phenyl)-3-(1-phenylethyl)urea
H1508
1-(4-(((2-methylisoindolin-5- yl)methyl)sulfonyl)-3-(oxazol-2- yl)phenyl)-3-(1-phenylethyl)urea
H1509
1-(1-(2,3-dichlorophenyl)ethyl)-1- hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1510
1-(1-(2-fluorophenyl)ethyl)-1- hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)-3- methoxyphenyl)urea
H1511
1-(1-(2-fluorophenyl)ethyl)-1- hydroxy-3-(3-methoxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)urea
H1512
1-(2-(2-hydroxypropan-2-yl)-4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1515
1-hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)-3- methoxyphenyl)-1-(1- phenylethyl)urea
H1516
1-hydroxy-3-(3-methoxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1517
1-hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)-2- methoxyphenyl)-1-(1- phenylethyl)urea
H1518
1-hydroxy-3-(2-methoxy-4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1519
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2-(1H-pyrazol-3- yl)phenyl)-3-(1-phenylethyl)urea
H1520
1-(3-(hydroxymethyl)-4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1521
1-(1-(3-(difluoromethyl)-4- methylphenyl)ethyl)-3-(4- ((isoindolin-5- ylmethyl)sulfonyl)phenyl)urea
H1523
1-(1-(2,3-dichlorophenyl)ethyl)-1- hydroxy-3-(2-methoxy-4-(((2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1524
1-hydroxy-3-(2-methoxy-4-(((3- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1525
1-hydroxy-3-(2-methoxy-4-(((2- methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1526
1-hydroxy-3-(4-((isoindolin-5- ylmethyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1527
1-hydroxy-3-(4-(((2- methylisoindolin-5- yl)methyl)sulfonyl)phenyl)-1-(1- phenylethyl)urea
H1528
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2-(1-methyl-1H- pyrazol-5-yl)phenyl)-3-(1- phenylethyl)urea
H1529
2-((isoindolin-5-ylmethyl)sulfonyl)- N-methyl-5-(3-1- phenylethyl)ureido)benzamide
H1530
2-((isoindolin-5-ylmethyl)sulfonyl)- 5-(3-(1-phenylethyl)ureido)benzoic acid
H1531
2-((isoindolin-5-ylmethyl)sulfonyl)- 5-(3-(1- phenylethyl)ureido)benzamide
H1532
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2-(1H-pyrazol-4- yl)phenyl)-3-(1-phenylethyl)urea
H1533
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2-(pyridin-3- yl)phenyl)-3-(1-phenylethyl)urea
H1534
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2-(pyridin-4- yl)phenyl)-3-(1-phenylethyl)urea
H1535
1-(4-((isoindolin-5- ylmethyl)sulfonyl)-2-(1-methyl-1H- pyrazol-4-yl)phenyl)-3-(1- phenylethyl)urea
H1537
1-((R)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((4-fluoro-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1538
1-((R)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((4-fluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1539
1-(4-(((4-fluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-((R)- 1-phenylethyl)urea
H1540
1-(4-(((4-fluoro-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-((R)- 1-phenylethyl)urea
H1541
2-(3-(1-phenylethyl)ureido)-5- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)benzoic acid
H1542
2-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-5- (((1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)benzoic acid
H1543
1-((R)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((4-fluoro-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)-2- methoxyphenyl)urea
H1544
1-((R)-1-(2,3-dichlorophenyl)ethyl)- 3-(4-(((4-fluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)-2- methoxyphenyl)urea
H1545
1-(4-(((4,4-difluoro-1,2,3,4 tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1546
1-(4-(((4,4-difluoro-2-methyl- 1,2,3,4-tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)-3-(1- phenylethyl)urea
H1547
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((4,4-difluoro-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1548
1-(1-(2,3-dichlorophenyl)ethyl)-3- (4-(((4,4-difluoro-2-methyl-1,2,3,4- tetrahydroisoquinolin-6- yl)methyl)sulfonyl)phenyl)urea
H1549
2-(3-(1-(2,3- dichlorophenyl)ethyl)ureido)-5- ((isoindolin-5- ylmethyl)sulfonyl)benzoic acid.

### Claim 34

A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.

### Claim 35 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 36 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 37 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable thereof.

### Claim 38 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 39 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 40 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 41 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 42 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 43 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 44 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 45 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 46 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 47 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 48 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 49 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 50 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.

### Claim 51 (depends on 34)

The compound of claim 34 having the structure:
or a pharmaceutically acceptable salt thereof.