# US 10,501,442 B2 · Quinoline derivative

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- Number: US 10,501,442 B2
- Document ID: US10501442B2
- Status: Granted
- Kind: B2
- Application number: 16/237,275
- Filed: 2018-12-31
- Published: 2019-05-09
- Granted: 2019-12-10
- Earliest claimed: 2013-07-24
- Assignees: Ono Pharmaceuticals Co., Ltd.
- Applicants: Ono Pharmaceutical Co., Ltd.
- Inventors: Takayuki Inukai; Jun Takeuchi; Tomoko Yasuhiro
- Web page: https://patentgrep.com/patent/US10501442B2

## CPC

- C07D 401/14: containing three or more hetero rings
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 13/12: of the kidneys
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 25/02: for peripheral neuropathies
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 35/04: specific for metastasis
- A61P 37/02: Immunomodulators
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 215/54: attached in position 3
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases

## Claims

### Claim 1

A pharmaceutical composition comprising a compound which is N-{5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl}-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxamide, or a salt thereof; and a pharmaceutically acceptable carrier.

### Claim 2

A pharmaceutical composition comprising a compound of the following chemical formula:
and
a pharmaceutically acceptable carrier.